Increased Expression of Angiotensin II Type 2 Receptors in the Solitary-Vagal Complex Blunts Renovascular Hypertension

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBlanch, Graziela Torres
dc.creatorFreiria-Oliveira, Andre Henrique
dc.creatorFina Speretta, Guilherme Fleury
dc.creatorCarrera, Eduardo J.
dc.creatorLi, Hongwei
dc.creatorSpeth, Robert C.
dc.creatorColombari, Eduardo
dc.creatorSumners, Colin
dc.creatorColombari, Debora S. A.
dc.date2015-03-18T15:55:39Z
dc.date2016-10-25T20:34:55Z
dc.date2015-03-18T15:55:39Z
dc.date2016-10-25T20:34:55Z
dc.date2014-10-01
dc.date.accessioned2017-04-06T07:15:37Z
dc.date.available2017-04-06T07:15:37Z
dc.identifierHypertension. Philadelphia: Lippincott Williams & Wilkins, v. 64, n. 4, p. 777-+, 2014.
dc.identifier0194-911X
dc.identifierhttp://hdl.handle.net/11449/117259
dc.identifierhttp://acervodigital.unesp.br/handle/11449/117259
dc.identifier10.1161/HYPERTENSIONAHA.114.03188
dc.identifierWOS:000341988000016
dc.identifierhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03188
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/927906
dc.descriptionAngiotensin II increases and decreases arterial pressure by acting at angiotensin type 1 and type 2 receptors, respectively. Renovascular hypertensive rats exhibit a high level of activity of the peripheral and central renin-angiotensin system. Therefore, in the present study, we evaluated the effect of increasing the expression of angiotensin type 2 receptors in the solitary-vagal complex (nucleus of the solitary tract/dorsal motor nucleus of the vagus), a key brain stem region for cardiovascular regulation, on the development of renovascular hypertension. Holtzman normotensive rats were implanted with a silver clip around the left renal artery to induce 2-kidney 1-clip renovascular hypertension. Three weeks later, rats were microinjected in the solitary-vagal complex with either an adenoassociated virus to increase the expression of angiotensin type 2 receptors or with a control vector. We observed that increasing angiotensin type 2 receptor expression in the solitary-vagal complex attenuated the development of renovascular hypertension and also reversed the impairment of the baroreflex and the increase in the low-frequency component of systolic blood pressure observed in renovascular hypertensive rats. Furthermore, an observed decrease in mRNA levels of angiotensin-converting enzyme 2 in the solitary-vagal complex of renovascular hypertensive rats was restored to control levels after viral-mediated increases in angiotensin type 2 receptors at this site. Collectively, these data demonstrate specific and beneficial effects of angiotensin type 2 receptors via the brain of hypertensive rats and suggest that central angiotensin type 2 receptors may be a potential target for therapeutics in renovascular hypertension.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherLippincott Williams & Wilkins
dc.relationHypertension
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectangiotensin II
dc.subjectangiotensin-converting enzyme 2
dc.subjectangiotensin receptor blockers
dc.subjectbaroreflex
dc.titleIncreased Expression of Angiotensin II Type 2 Receptors in the Solitary-Vagal Complex Blunts Renovascular Hypertension
dc.typeOtro


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