Objective CT-Based Quantification of Lung Sequelae in Treated Patients With Paracoccidioidomycosis

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAlvarez, Matheus
dc.creatorMiranda, Diana Rodrigues de Pina
dc.creatorOliveira, Marcela de
dc.creatorRibeiro, Sergio Marrone
dc.creatorMendes, Rinaldo Poncio
dc.creatorDuarte, Sergio B.
dc.creatorMiranda, Jose R. A.
dc.date2015-03-18T15:54:44Z
dc.date2016-10-25T20:32:03Z
dc.date2015-03-18T15:54:44Z
dc.date2016-10-25T20:32:03Z
dc.date2014-11-01
dc.date.accessioned2017-04-06T07:10:36Z
dc.date.available2017-04-06T07:10:36Z
dc.identifierMedicine. Philadelphia: Lippincott Williams & Wilkins, v. 93, n. 25, 6 p., 2014.
dc.identifier0025-7974
dc.identifierhttp://hdl.handle.net/11449/117018
dc.identifierhttp://acervodigital.unesp.br/handle/11449/117018
dc.identifier10.1097/MD.0000000000000167
dc.identifierWOS:000345559000010
dc.identifierhttp://dx.doi.org/10.1097/MD.0000000000000167
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/927665
dc.descriptionThis study presents methodology for objectively quantifying the pulmonary region affected by emphysemic and fibrotic sequelae in treated patients with paracoccidioidomycosis. This methodology may also be applied to any other disease that results in these sequelae in the lungs.Pulmonary high-resolution computed tomography examinations of 30 treated paracoccidioidomycosis patients were used in the study. The distribution of voxel attenuation coefficients was analyzed to determine the percentage of lung volume that consisted of emphysemic, fibrotic, and normal tissue. Algorithm outputs were compared with subjective evaluations by radiologists using a scale that is currently used for clinical diagnosis.Affected regions in the patient images were determined by computational analysis and compared with estimates by radiologists, revealing mean (+/- standard deviation) differences in the scores for fibrotic and emphysemic regions of 0.1% +/- 1.2% and +/- 0.2% +/- 1.0%, respectively.The computational results showed a strong correlation with the radiologist estimates, but the computation results were more reproducible, objective, and reliable.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherLippincott Williams & Wilkins
dc.relationMedicine
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleObjective CT-Based Quantification of Lung Sequelae in Treated Patients With Paracoccidioidomycosis
dc.typeOtro


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