Metabolic Syndrome Criteria As Predictors of Insulin Resistance, Inflammation and Mortality in Chronic Hemodialysis Patients

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorVogt, Barbara Perez
dc.creatorSouza, Priscilla L.
dc.creatorMinicucci, Marcos Ferreira
dc.creatorMartin, Luis Cuadrado
dc.creatorBarretti, Pasqual
dc.creatorCaramori, Jacqueline Socorro Costa Teixeira
dc.date2015-03-18T15:54:42Z
dc.date2016-10-25T20:31:59Z
dc.date2015-03-18T15:54:42Z
dc.date2016-10-25T20:31:59Z
dc.date2014-10-01
dc.date.accessioned2017-04-06T07:10:22Z
dc.date.available2017-04-06T07:10:22Z
dc.identifierMetabolic Syndrome And Related Disorders. New Rochelle: Mary Ann Liebert, Inc, v. 12, n. 8, p. 443-449, 2014.
dc.identifier1540-4196
dc.identifierhttp://hdl.handle.net/11449/116994
dc.identifierhttp://acervodigital.unesp.br/handle/11449/116994
dc.identifier10.1089/met.2014.0011
dc.identifierWOS:000342152500006
dc.identifierhttp://dx.doi.org/10.1089/met.2014.0011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/927641
dc.descriptionBackground: Chronic kidney disease (CKD) and metabolic syndrome are characterized by overlapping disorders, including glucose intolerance, hypertension, dyslipidemia, and, in some cases, obesity. However, there are no specific criteria for the diagnosis of metabolic syndrome in CKD. Metabolic syndrome can also be associated with increased risk of mortality. Some traditional risk factors may protect dialysis patients from mortality, known as "reverse epidemiology." Metabolic syndrome might undergo reverse epidemiology. The objectives were to detect differences in frequency and metabolic characteristics associated with three sets of diagnostic criteria for metabolic syndrome, to evaluate the accuracy of insulin resistance (IR) and inflammation to identify patients with metabolic syndrome, and to investigate the effects of metabolic syndrome by three sets of diagnostic criteria on mortality in chronic hemodialysis patients.Methods: An observational study was conducted. Diagnostic criteria for metabolic syndrome proposed by National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), International Diabetes Federation (IDF), and Harmonizing the Metabolic Syndrome (HMetS) statement were applied to 98 hemodialysis patients.Results: The prevalence of metabolic syndrome was 51%, 66.3%, and 75.3% according to NCEP ATP III, IDF, and HMetS criteria, respectively. Diagnosis of metabolic syndrome by HMetS was simultaneously capable of revealing both inflammation and IR, whereas NCEP ATP III and IDF criteria were only able to identify IR. Mortality risk increased in the presence of metabolic syndrome regardless of the criteria used.Conclusions: The prevalence of metabolic syndrome in hemodialysis varies according to the diagnostic criteria used. IR and inflammation predict metabolic syndrome only when diagnosed by HMetS criteria. HMetS was the diagnostic criteria that can predict the highest risk of mortality.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherMary Ann Liebert, Inc
dc.relationMetabolic Syndrome And Related Disorders
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleMetabolic Syndrome Criteria As Predictors of Insulin Resistance, Inflammation and Mortality in Chronic Hemodialysis Patients
dc.typeOtro


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