5CN05 partitioning in an aqueous two-phase system: A new approach to the solubilization of hydrophobic drugs

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorLopes, Andre Moreni
dc.creatorSantos-Ebinuma, Valeria de Carvalho
dc.creatorApolinario, Alexsandra Conceicao
dc.creatorBezerra Mendonca, Francisco Jaime
dc.creatorGoulart de Lima Damasceno, Bolivar Ponciano
dc.creatorPessoa, Adalberto
dc.creatorSilva, Jose Alexsandro da
dc.date2015-03-18T15:53:59Z
dc.date2016-10-25T20:27:54Z
dc.date2015-03-18T15:53:59Z
dc.date2016-10-25T20:27:54Z
dc.date2014-09-01
dc.date.accessioned2017-04-06T07:06:45Z
dc.date.available2017-04-06T07:06:45Z
dc.identifierProcess Biochemistry. Oxford: Elsevier Sci Ltd, v. 49, n. 9, p. 1555-1561, 2014.
dc.identifier1359-5113
dc.identifierhttp://hdl.handle.net/11449/116717
dc.identifierhttp://acervodigital.unesp.br/handle/11449/116717
dc.identifier10.1016/j.procbio.2014.05.017
dc.identifierWOS:000341549600024
dc.identifierhttp://dx.doi.org/10.1016/j.procbio.2014.05.017
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/927364
dc.descriptionLiquid-liquid extraction for the purification of molecules has been central to many advances in the pharmaceutical industry. These processes were developed based on the property that some polymer and/or micellar solutions present to separate into a concentrated phase and a diluted phase. Based on the differences in the physical and chemical environments of the two coexisting phases, and since both phases contain approximately 60-90% of water, liquid-liquid extraction provides a powerful alternative to both extract and solubilize a molecule. This paper examines the partition behavior of the synthetic drug, 2-[(3,4-dichlorine-benzylidene)-amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (5CN05), in an aqueous two-phase polymer system (ATPPS) and also in an aqueous two-phase micellar system (ATPMS). The results showed that both systems are favorable for extraction the 5CN05 drug high partition coefficient values (K-5CN05 > 200) and yield (Y-5CN05 > 99.48%) in the concentrated phase were achieved with the systems. However, the ATPPS generated a partition coefficient (K-5CN05) higher than the one obtained with ATPMS. The results suggest that both processes may be used for the extraction and concentration of molecules with hydrophobic characteristics, such as 5CN05. They also provide an optimal environment for the solubilization of such molecules, allowing for greater efficiency when purifying many classes of drugs. (C) 2014 Elsevier Ltd. All rights reserved.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationProcess Biochemistry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPEG
dc.subjectTriton X-114
dc.subject5CN05
dc.subjectLiquid-liquid extraction
dc.subjectAqueous two-phase systems
dc.title5CN05 partitioning in an aqueous two-phase system: A new approach to the solubilization of hydrophobic drugs
dc.typeOtro


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