Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAloisio, Carolina
dc.creatorOliveira, Anselmo Gomes de
dc.creatorLonghi, Marcela
dc.date2015-03-18T15:53:38Z
dc.date2016-10-25T20:25:15Z
dc.date2015-03-18T15:53:38Z
dc.date2016-10-25T20:25:15Z
dc.date2014-11-01
dc.date.accessioned2017-04-06T07:04:40Z
dc.date.available2017-04-06T07:04:40Z
dc.identifierJournal Of Pharmaceutical And Biomedical Analysis. Amsterdam: Elsevier Science Bv, v. 100, p. 64-73, 2014.
dc.identifier0731-7085
dc.identifierhttp://hdl.handle.net/11449/116632
dc.identifierhttp://acervodigital.unesp.br/handle/11449/116632
dc.identifier10.1016/j.jpba.2014.07.008
dc.identifierWOS:000343021100009
dc.identifierhttp://dx.doi.org/10.1016/j.jpba.2014.07.008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/927279
dc.descriptionThis study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with beta-(beta CD), methyl-(M beta CD) and hydroxypropyl-P-cyclodextrin (HP beta CD) using meglumine (MEG) as the ternary component. The combination of MEG with M beta CD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and M beta CD or HP beta CD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and M beta CD or HP beta CD in the ternary lyophilized systems. The ternary complexes with beta CD and M beta CD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation. (C) 2014 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal Of Pharmaceutical And Biomedical Analysis
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSulfamerazine
dc.subjectCyclodextrin
dc.subjectTernary complex
dc.subjectSolubility
dc.subjectIn vitro-release
dc.titleSolubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine
dc.typeOtro


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