Blood Profile and Histology in Oral Infections Associated with Diabetes

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCintra, Luciano Tavares Angelo
dc.creatorSilva Facundo, Aguinaldo Candido da
dc.creatorCarrara Prieto, Annelise Katrine
dc.creatorSumida, Doris Hissako
dc.creatorNarciso, Luis Gustavo
dc.creatorBomfim, Suely Regina Mogami
dc.creatorOliveira e Silva, Cleverson
dc.creatorDezan Júnior, Eloi
dc.creatorGomes-Filho, Joao Eduardo
dc.date2015-03-18T15:53:37Z
dc.date2016-10-25T20:25:14Z
dc.date2015-03-18T15:53:37Z
dc.date2016-10-25T20:25:14Z
dc.date2014-08-01
dc.date.accessioned2017-04-06T07:04:35Z
dc.date.available2017-04-06T07:04:35Z
dc.identifierJournal Of Endodontics. New York: Elsevier Science Inc, v. 40, n. 8, p. 1139-1144, 2014.
dc.identifier0099-2399
dc.identifierhttp://hdl.handle.net/11449/116625
dc.identifierhttp://acervodigital.unesp.br/handle/11449/116625
dc.identifier10.1016/j.joen.2014.01.034
dc.identifierWOS:000340686400016
dc.identifierhttp://dx.doi.org/10.1016/j.joen.2014.01.034
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/927272
dc.descriptionIntroduction: We aimed to investigate the relationship between blood profile and histologic findings in both apical periodontitis (AP) and periodontal disease (PD) associated with diabetes. Methods: Wistar rats (N = 80) were assigned to the following 8 groups: control, AP, PD, AP associated with PD, diabetes, diabetes with AP, diabetes with PD, and diabetes with AP and PD. Diabetes mellitus (DM) was induced with streptozotocin, AP was induced by exposure to the oral environment, and PD was induced using periodontal ligature. After 30 days, blood samples were collected, and the rats were euthanized. Subsequently, the maxillae were processed for light microscopy. Hematologic examinations were conducted to determine the total number of erythrocytes and leukocytes, erythrocyte constant, and blood glucose level. One-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at P < .05. Results: A significant correlation was found between the histologic findings and blood parameters. Conclusions: In conclusion, diabetes accelerated the development and progression of AP and PD in the rats and caused an increase in the average erythrocyte volume as well as the leukocyte and neutrophil counts. Oral infections increase the total number of leukocytes, the number of neutrophils and lymphocytes, and blood glucose concentrations in DM rats.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal Of Endodontics
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApical periodontitis
dc.subjectblood count
dc.subjectdiabetes
dc.subjectoral infections
dc.subjectperiodontal disease
dc.titleBlood Profile and Histology in Oral Infections Associated with Diabetes
dc.typeOtro


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