Spectroscopic, luminescence and in vitro biological studies of solid ketoprofen of heavier trivalent lanthanides and yttrium(III)

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGalico, D. A.
dc.creatorLahoud, M. G.
dc.creatorDavolos, Marian Rosaly
dc.creatorFrem, Regina Célia Galvão
dc.creatorFraga-Silva, T. F. C.
dc.creatorVenturini, J.
dc.creatorArruda, M. S. P.
dc.creatorBannach, G.
dc.date2015-03-18T15:53:35Z
dc.date2016-10-25T20:25:12Z
dc.date2015-03-18T15:53:35Z
dc.date2016-10-25T20:25:12Z
dc.date2014-11-01
dc.date.accessioned2017-04-06T07:04:26Z
dc.date.available2017-04-06T07:04:26Z
dc.identifierJournal Of Inorganic Biochemistry. New York: Elsevier Science Inc, v. 140, p. 160-166, 2014.
dc.identifier0162-0134
dc.identifierhttp://hdl.handle.net/11449/116610
dc.identifierhttp://acervodigital.unesp.br/handle/11449/116610
dc.identifier10.1016/j.jinorgbio.2014.07.008
dc.identifierWOS:000342608900020
dc.identifierhttp://dx.doi.org/10.1016/j.jinorgbio.2014.07.008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/927257
dc.descriptionSolid-state compounds of the general formulae [ML3] (M = Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y; L = ketoprofen) were synthesized and characterized using infrared, diffuse reflectance and luminescence spectroscopies. IR data suggested that the carboxylate group in ketoprofen is coordinated to the metals as a bidentate ligand. The triplet state energy level was determined using the Gd3+ complex, which exhibited a ketoprofen blue luminescence when excited in the UV region. The compound containing Tb3+ ion was sensitized by the ligand and emitted in the green region of the visible spectrum. On the other hand, for the analogous species containing the dysprosium ion, a competition for luminescence between the Dy3+ and the ligand levels was observed. Finally, Tm3+ complex exhibits only ligand luminescence. These optical behaviors are discussed based on rare earth energy diagrams. In addition, the compounds were evaluated for their anti-inflammatory activities. All the compounds showed a higher production of H2O2 and IL-10 than the ketoprofen, suggesting that the compounds exhibited an immunomodulatory effect and this opens up new perspectives for immunotherapeutic approaches. (C) 2014 Elsevier Inc. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal Of Inorganic Biochemistry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKetoprofen
dc.subjectLanthanide complexes
dc.subjectInfrared spectroscopy
dc.subjectCarboxylate coordination
dc.subjectLanthanide luminescence
dc.subjectBiological studies
dc.titleSpectroscopic, luminescence and in vitro biological studies of solid ketoprofen of heavier trivalent lanthanides and yttrium(III)
dc.typeOtro


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