Frequency of HLA-B27 alleles in Brazilian patients with psoriatic arthritis

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBonfiglioli, Rubens
dc.creatorConde, Roseneide A.
dc.creatorSampaio-Barros, Percival D.
dc.creatorLouzada-Junior, Paulo
dc.creatorDonadi, Eduardo A.
dc.creatorBertolo, Manoel B.
dc.date2015-03-18T15:53:00Z
dc.date2016-10-25T20:24:26Z
dc.date2015-03-18T15:53:00Z
dc.date2016-10-25T20:24:26Z
dc.date2008-06-01
dc.date.accessioned2017-04-06T07:01:04Z
dc.date.available2017-04-06T07:01:04Z
dc.identifierClinical Rheumatology. London: Springer London Ltd, v. 27, n. 6, p. 709-712, 2008.
dc.identifier0770-3198
dc.identifierhttp://hdl.handle.net/11449/116286
dc.identifierhttp://acervodigital.unesp.br/handle/11449/116286
dc.identifier10.1007/s10067-007-0770-3
dc.identifierWOS:000255617500005
dc.identifierhttp://dx.doi.org/10.1007/s10067-007-0770-3
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/926935
dc.descriptionThis prospective study analyzed the frequency of HLA-B27 and its alleles in 102 Brazilian patients with psoriatic arthritis (PsA). The association of the HLA-B27 alleles with these variants was compared to a control healthy HLA-B27 positive group of 111 individuals. There was a predominance of male gender (59.8%), Caucasian race (89.2%), and negative HLA-B27 (79.4%) patients. Asymmetric oligoarthritis (62.7%) was the most frequently observed clinical PsA subgroup, followed by spondylitis (16.7%), and polyarthritis (15.7%). Male gender and the spondylitis subgroup were statistically associated to the positive HLA-B27, and the oligoarthritis subgroup was associated to the negative HLA-B27. Among the 21 HLA-B27-positive PsA patients, there was a significant prevalence of the HLA-B*2705 allele (90.5%), similar to that observed in the control group (80.2%); HLA-B*2703 and HLA-B*2707 were statistically associated to the control group.
dc.languageeng
dc.publisherSpringer
dc.relationClinical Rheumatology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectB27-human histocompatibility antigen
dc.subjectB*27 alleles
dc.subjectpsoriatic arthritis
dc.titleFrequency of HLA-B27 alleles in Brazilian patients with psoriatic arthritis
dc.typeOtro


Este ítem pertenece a la siguiente institución