| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Nogueira, M. N. M. | |
| dc.creator | Aquino, S. G. | |
| dc.creator | Rossa Júnior, Carlos | |
| dc.creator | Spolidório, Denise Madalena Palomari | |
| dc.date | 2015-03-18T15:52:55Z | |
| dc.date | 2016-10-25T20:24:20Z | |
| dc.date | 2015-03-18T15:52:55Z | |
| dc.date | 2016-10-25T20:24:20Z | |
| dc.date | 2014-09-01 | |
| dc.date.accessioned | 2017-04-06T07:00:38Z | |
| dc.date.available | 2017-04-06T07:00:38Z | |
| dc.identifier | Inflammation Research. Basel: Springer Basel Ag, v. 63, n. 9, p. 769-778, 2014. | |
| dc.identifier | 1023-3830 | |
| dc.identifier | http://hdl.handle.net/11449/116242 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/116242 | |
| dc.identifier | 10.1007/s00011-014-0749-x | |
| dc.identifier | WOS:000340557100007 | |
| dc.identifier | http://dx.doi.org/10.1007/s00011-014-0749-x | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/926891 | |
| dc.description | Tea tree oil (TTO) is an essential oil with anti-inflammatory properties, steam distilled from the plant Melaleuca alternifolia. We investigated the immunomodulatory properties of TTO and its components (terpinen-4-ol and alpha-terpineol) using lipopolysaccharide (LPS)-stimulated macrophages.The ability of TTO, terpinen-4-ol and alpha-terpineol to modulate the macrophage response to bacterial LPS stimulation was assessed by ELISA for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6 and IL-10 cytokine production and by western blotting for the activation of nuclear factor kappa B (NF-kappa B) and p38 mitogen-activated protein kinase (MAPK) signaling, which are associated with the expression of pro-inflammatory cytokines. We used a human monocytic cell line (U937) differentiated into macrophages.LPS induced the production of all cytokines, and TTO and its components significantly reduced the production of IL-1 beta, IL-6 and IL-10. The production of TNF-alpha was not affected by either TTO or its major components. The modulation of cytokine production was not mediated by changes in NF-kappa B or p38 MAPK activation.TTO, terpinen-4-ol and alpha-terpineol can suppress the production of inflammatory mediators in LPS-stimulated human macrophages; this inhibition was mediated by interfering with the NF-kB, p38 or ERK MAPK pathways. | |
| dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.language | eng | |
| dc.publisher | Springer | |
| dc.relation | Inflammation Research | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | Tea tree oil | |
| dc.subject | Macrophages | |
| dc.subject | Cytokines | |
| dc.subject | Inflammation | |
| dc.title | Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1 beta, IL-6 and IL-10 on human macrophages | |
| dc.type | Otro | |
