Síndrome reno-pulmonar por lupus eritematoso sistémico asociado a ANCA p: Un reporte de caso

Reno pulmonary syndrome due to systemic lupus erythematosus associated with ANCA p: A case report

dc.creatorGuacho Guacho, Juan Sebastián
dc.creatorPinos Cedeño, María José
dc.creatorCruz Castillo, Yessenia Magaly
dc.creatorMarín Molina, Heidi Cristina
dc.date2020-09-30
dc.date.accessioned2024-04-29T17:02:09Z
dc.date.available2024-04-29T17:02:09Z
dc.identifierhttps://cienciadigital.org/revistacienciadigital2/index.php/AnatomiaDigital/article/view/1411
dc.identifier10.33262/anatomiadigital.v3i4.1411
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9254601
dc.descriptionIntroducción: El término síndrome pulmonar – renal (SPR)  se define como falla pulmonar y renal producida por hemorragia alveolar difusa y glomerulonefritis rápidamente progresiva. Su patogenia se debe a una variedad de mecanismos inmunomediados la cual se relaciona con el depósito de anticuerpos antiglomerulares de la membrana basal, anticuerpos anticitoplasma de neutrófilos, inmunocomplejos y microangiopatía trombótica. Dado que el síndrome se caracteriza por un curso fulminante si no se trata, el diagnóstico precoz, la exclusión de la infección, la monitorización estrecha y el inicio oportuno del tratamiento son cruciales para el resultado del paciente. El tratamiento consiste en soporte ventilatorio, sustitución de la función renal, corticosteroides en dosis altas y agentes citotóxicos. El trasplante renal es la única alternativa en la enfermedad renal en etapa terminal. La asociación de Lupus Eritematoso Sistémico (LES) con resultados de Anticuerpos Anticitoplasma de Neutrófilos (ANCA) no necesariamente indica que se trate además de una Vasculitis si faltan criterios para esta última, pero si le confieren un peor pronóstico Objetivo: Presentar el caso de una paciente con SPR por LES más presencia de Anca p del Hospital Regional Ambato. Metodología: Se tomaron los datos mediante entrevista directa y se complementaron con la revisión de la historia clínica física de la paciente con el debido consentimiento informado.  Resultados: Revisión actualizada de la patogénesis, el abordaje diagnóstico y tratamiento del SRP.  es-ES
dc.descriptionIntroduction: The term pulmonary-renal syndrome (PRS) is defined as pulmonary and renal failure caused by diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis. Its pathogenesis is due to a variety of immune-mediated mechanisms which is related to the deposition of antiglomerular basement membrane antibodies, antineutrophil cytoplasmic antibodies, immune complexes, and thrombotic microangiopathy. Since the syndrome is characterized by a fulminant course if left untreated, early diagnosis, exclusion of infection, close monitoring, and timely initiation of treatment are crucial for patient outcome. Treatment consists of ventilatory support, replacement of renal function, high-dose corticosteroids, and cytotoxic agents. Kidney transplantation is the only alternative in end-stage renal disease. The association of Systemic Lupus Erythematosus (SLE) with results of Antibody Neutrophil Cytoplasm (ANCA) does not necessarily indicate that it is also a Vasculitis if criteria for the latter are lacking, but if they confer a worse prognosis. Objective: To present the case of a patient with SPR due to SLE plus the presence of Anca p from Hospital Regional Ambato. Methodology: Data were collected by direct interview and supplemented with review of the patient's physical medical history with the due informed consent. Results: Updated review of the pathogenesis, diagnostic approach and treatment of PRS.       Introduction: The term pulmonary-renal syndrome (PRS) is defined as pulmonary and renal failure caused by diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis. Its pathogenesis is due to a variety of immune-mediated mechanisms which is related to the deposition of antiglomerular basement membrane antibodies, antineutrophil cytoplasmic antibodies, immune complexes, and thrombotic microangiopathy. Since the syndrome is characterized by a fulminant course if left untreated, early diagnosis, exclusion of infection, close monitoring, and timely initiation of treatment are crucial for patient outcome. Treatment consists of ventilatory support, replacement of renal function, high-dose corticosteroids, and cytotoxic agents. Kidney transplantation is the only alternative in end-stage renal disease. The association of Systemic Lupus Erythematosus (SLE) with results of Antibody Neutrophil Cytoplasm (ANCA) does not necessarily indicate that it is also a Vasculitis if criteria for the latter are lacking, but if they confer a worse prognosis. Objective: To present the case of a patient with SPR due to SLE plus the presence of Anca p from Hospital Regional Ambato. Methodology: Data were collected by direct interview and supplemented with review of the patient's physical medical history with the due informed consent. Results: Updated review of the pathogenesis, diagnostic approach and treatment of PRS.        en-US
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dc.formattext/plain
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dc.languagespa
dc.publisherEditorial Ciencia digital Registrada en la Cámara Ecuatoriana del Libro No Afiliación 663 (Editor DrC. Efraín Velasteguí López. PhD.)es-ES
dc.relationhttps://cienciadigital.org/revistacienciadigital2/index.php/AnatomiaDigital/article/view/1411/3489
dc.relationhttps://cienciadigital.org/revistacienciadigital2/index.php/AnatomiaDigital/article/view/1411/3492
dc.relationhttps://cienciadigital.org/revistacienciadigital2/index.php/AnatomiaDigital/article/view/1411/3493
dc.rightsDerechos de autor 2020 Anatomía Digitales-ES
dc.sourceAnatomía Digital; Vol. 3 No. 4 (2020): Disease prevention; 24-32en-US
dc.sourceAnatomía Digital; Vol. 3 Núm. 4 (2020): Prevención de enfermedades; 24-32es-ES
dc.sourceAnatomía Digital; v. 3 n. 4 (2020): Prevención de enfermedades; 24-32pt-BR
dc.source2697-3391
dc.source2697-3391
dc.source10.33262/anatomiadigital.v3i4
dc.subjectKidney Lung Syndrome, Diffuse Alveolar Hemorrhage, Acute Kidney Injury.en-US
dc.subjectSíndrome Pulmón Riñón, Hemorragia Alveolar Difusa, Lesión Renal Agudaes-ES
dc.titleSíndrome reno-pulmonar por lupus eritematoso sistémico asociado a ANCA p: Un reporte de casoes-ES
dc.titleReno pulmonary syndrome due to systemic lupus erythematosus associated with ANCA p: A case reporten-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeArtículo revisado por pareses-ES


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