Ascorbic acid iontophoresis for chondral gain in rats with arthritis

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorArruda, Mauricio Ferraz de
dc.creatorCassettari, Lucas Langoni
dc.creatorNeves, Lais Mara Siqueira das
dc.creatorOliveira, Olga Maria Mascarenhas de Faria
dc.creatorMarcolino, Alexandre Márcio
dc.date2015-02-02T12:39:25Z
dc.date2016-10-25T20:16:49Z
dc.date2015-02-02T12:39:25Z
dc.date2016-10-25T20:16:49Z
dc.date2014-07-01
dc.date.accessioned2017-04-06T06:42:24Z
dc.date.available2017-04-06T06:42:24Z
dc.identifierActa Ortopédica Brasileira. Sociedade Brasileira de Ortopedia e Traumatologia, v. 22, n. 4, p. 202-205, 2014.
dc.identifier1413-7852
dc.identifierhttp://hdl.handle.net/11449/114312
dc.identifierhttp://acervodigital.unesp.br/handle/11449/114312
dc.identifier10.1590/1413-78522014220400769
dc.identifierS1413-78522014000400202
dc.identifierS1413-78522014000400202.pdf
dc.identifierhttp://dx.doi.org/10.1590/1413-78522014220400769
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/925027
dc.descriptionOBJECTIVES: To examine the cellularity and thickness of the articular cartilage of the femur in rats with arthritis after treatment with iontophoresis. METHODS: To evaluate these objectives, a histological analysis was performed on hematoxylin and eosin, where cellularity and cartilage thickness were observed and evaluated qualitatively and quantitatively by manual counting by 700.09µm² area. RESULTS: The group treated with IAA had normal cellularity (40.1 cells/μm2) and maintenance of non-calcified cartilage (75.5μm), suggesting normal thickness. The non-treated group C+, on the other hand, had a lower mean number of chondrocytes (13.0μm2) (P <0.05) and, when the cartilage thickness was compared, it showed higher average thickness of calcified cartilage (104.8 mm) and lower mean of non-calcified cartilage (53.3μm) CONCLUSION: The use of iontophoresis with L-ascorbic acid by continuous electric current contributed to a quantitative gain of chondrocytes and improved the thickness distribution of calcified and non-calcified cartilage. Level of Evidence III, Case Control Study.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherSociedade Brasileira de Ortopedia e Traumatologia
dc.relationActa Ortopédica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIontophoresis
dc.subjectCartilage
dc.subjectAscorbic acid
dc.titleAscorbic acid iontophoresis for chondral gain in rats with arthritis
dc.typeOtro


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