Proposta de um protocolo de terapia celular para o tratamento da doença pulmonar obstrutiva crônica

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRibeiro-Paes, J. T.
dc.creatorStessuk, T.
dc.creatorMarcelino, M.
dc.creatorFaria, C.
dc.creatorMarinelli, T.
dc.creatorRibeiro-Paes, M. J.
dc.date2014-12-03T13:11:37Z
dc.date2016-10-25T20:14:39Z
dc.date2014-12-03T13:11:37Z
dc.date2016-10-25T20:14:39Z
dc.date2014-03-01
dc.date.accessioned2017-04-06T06:32:24Z
dc.date.available2017-04-06T06:32:24Z
dc.identifierRevista Portuguesa De Pneumologia. Barcelona: Elsevier Doyma Sl, v. 20, n. 2, p. 84-91, 2014.
dc.identifier0873-2159
dc.identifierhttp://hdl.handle.net/11449/113335
dc.identifierhttp://acervodigital.unesp.br/handle/11449/113335
dc.identifier10.1016/j.rppneu.2013.06.008
dc.identifierWOS:000334263100007
dc.identifierhttp://dx.doi.org/10.1016/j.rppneu.2013.06.008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/924082
dc.descriptionThe main feature of pulmonary emphysema is airflow obstruction resulting from the destruction of the alveolar walls distal to the terminal bronchioles. Existing clinical approaches have improved and extended the quality of life of emphysema patients. However, no treatment currently exists that can change the disease course and cure the patient. The different therapeutic approaches that are available aim to increase survival and/or enhance the quality of life of emphysema patients. In this context, cell therapy is a promising therapeutic approach with great potential for degenerative pulmonary diseases. In this protocol proposition, all patients will be submitted to laboratory tests, such as evaluation of heart and lung function and routine examinations. Stem cells will be harvested by means of 10 punctures on each anterior iliac crest, collecting a total volume of 200 mL bone marrow. After preparation, separation, counting and labeling (optional) of the mononuclear cells, the patients will receive an intravenous infusion from the pool of Bone Marrow Mononuclear Cells (BMMC). This article proposes a rational and safe clinical cellular therapy protocol which has the potential for developing new projects and can serve as a methodological reference for formulating clinical application protocols related to the use of cellular therapy in COPD. This study protocol was submitted and approved by the Brazilian National Committee of Ethics in Research (CONEP - Brazil) registration number 14764. It is also registered in ClinicalTrials.gov (NCT01110252). (c) 2013 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L. All rights reserved.
dc.languagepor
dc.publisherElsevier B.V.
dc.relationRevista Portuguesa de Pneumologia
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCell therapy
dc.subjectChronic obstructive pulmonary disease
dc.subjectPulmonary emphysema
dc.subjectStern cells
dc.titleProposta de um protocolo de terapia celular para o tratamento da doença pulmonar obstrutiva crônica
dc.typeOtro


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