Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBrandt, Joyce Zalotti
dc.creatorSilveira, Livia Teresa R.
dc.creatorGrassi, Tony Fernando
dc.creatorAnselmo-Franci, Janete A.
dc.creatorFavaro, Wagner Jose
dc.creatorFelisbino, Sergio Luis
dc.creatorBarbisan, Luis Fernando
dc.creatorScarano, Wellerson Rodrigo
dc.date2014-12-03T13:10:57Z
dc.date2016-10-25T20:11:44Z
dc.date2014-12-03T13:10:57Z
dc.date2016-10-25T20:11:44Z
dc.date2014-01-01
dc.date.accessioned2017-04-06T06:24:46Z
dc.date.available2017-04-06T06:24:46Z
dc.identifierReproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 43, p. 56-66, 2014.
dc.identifier0890-6238
dc.identifierhttp://hdl.handle.net/11449/112670
dc.identifierhttp://acervodigital.unesp.br/handle/11449/112670
dc.identifier10.1016/j.reprotox.2013.11.001
dc.identifierWOS:000331028900008
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2013.11.001
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/923430
dc.descriptionBisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 mu g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate. (C) 2013 Elsevier Inc. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationReproductive Toxicology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBisphenol A
dc.subjectProstate
dc.subjectInflammation
dc.subjectIndole-3-carbinol
dc.subjectChemoprevention
dc.subjectReproductive toxicology
dc.titleIndole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats
dc.typeOtro


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