Geraniol-a flavoring agent with multifunctional effects in protecting the gastric and duodenal mucosa

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMoraes de Carvalho, Katharinne Ingrid
dc.creatorBonamin, Flavia
dc.creatorSantos, Raquel Cassia dos
dc.creatorPerico, Larissa Lucena
dc.creatorBeserra, Fernando Pereira
dc.creatorSousa, Damio Pergentino de
dc.creatorBarbosa Filho, Jose Maria
dc.creatorMachado da Rocha, Lucia Regina
dc.creatorHiruma-Lima, Clelia Akiko
dc.date2014-12-03T13:10:53Z
dc.date2016-10-25T20:11:37Z
dc.date2014-12-03T13:10:53Z
dc.date2016-10-25T20:11:37Z
dc.date2014-04-01
dc.date.accessioned2017-04-06T06:24:16Z
dc.date.available2017-04-06T06:24:16Z
dc.identifierNaunyn-schmiedebergs Archives Of Pharmacology. New York: Springer, v. 387, n. 4, p. 355-365, 2014.
dc.identifier0028-1298
dc.identifierhttp://hdl.handle.net/11449/112621
dc.identifierhttp://acervodigital.unesp.br/handle/11449/112621
dc.identifier10.1007/s00210-013-0947-z
dc.identifierWOS:000333429700006
dc.identifier0000-0002-8645-3777
dc.identifierhttp://dx.doi.org/10.1007/s00210-013-0947-z
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/923381
dc.descriptionGeraniol is an acyclic monoterpene alcohol commonly used as a flavoring agent. The present study was undertaken to investigate antiulcerogenic effects of geraniol and to determine the possible mechanisms involved in this action. In the model of the ethanol-induced ulcer, treatment of rats with geraniol by oral route significantly inhibited gastric lesions by 70 % (7.50 mg/kg) to 99 % (200 mg/kg). Analysis of the gastric tissue of rats treated with geraniol (7.50 mg/kg) revealed that total glutathione content levels (GSH) increased and levels of myeloperoxidase (MPO) decreased in the gastric mucosa. Oral treatment with geraniol significantly decreased the number of ulcerative lesions induced by ischemia/reperfusion injury by 71 % and the duodenal ulcers induced by cysteamine by 68 %. The action of geraniol was mediated by the activation of defensive mucosa-protective factors such as the nitric oxide (NO) pathway, endogenous prostaglandins, increased mucus production, increased sulfhydryl compounds, antioxidant properties and the stimulation of calcitonin gene-related peptide (CGRP) release through the activation of transient receptor potential vanilloid (TRPV). The multifaceted gastroprotective mechanisms of geraniol represent a promising option for the treatment of gastric and duodenal mucosa injury.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherSpringer
dc.relationNaunyn-schmiedebergs Archives of Pharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGeraniol
dc.subjectMonoterpene
dc.subjectGastric ulcer
dc.subjectDuodenal ulcer
dc.subjectMultifunctional effects
dc.titleGeraniol-a flavoring agent with multifunctional effects in protecting the gastric and duodenal mucosa
dc.typeOtro


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