dc.contributor | Riveros Ramirez, Maribel Denise | |
dc.contributor | Pons Casellas, Maria Jesus | |
dc.contributor | Ruiz Blazquez, Joaquim | |
dc.date.accessioned | 2024-02-23T16:10:52Z | |
dc.date.accessioned | 2024-04-24T13:28:44Z | |
dc.date.available | 2024-02-23T16:10:52Z | |
dc.date.available | 2024-04-24T13:28:44Z | |
dc.date.created | 2024-02-23T16:10:52Z | |
dc.date.issued | 2023 | |
dc.identifier | 203912 | |
dc.identifier | https://hdl.handle.net/20.500.12866/15049 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9232250 | |
dc.description.abstract | El presente estudio tuvo como objetivo determinar los niveles de resistencia a los antimicrobianos y clonalidad de Escherichia coli productoras de β-lactamasas de espectro extendido (BLEE) aisladas de tres diferentes orígenes: Clínica humana, carne expendida de mercado y aves silvestres de vida libre de la zona sur de Lima. Se recolectaron 125 muestras (63 muestras clínicas humanas, 21 muestras de carne de mercados y 41 muestras de hisopado cloacal y heces frescas de aves silvestres de vida libre). Se aisló e identifico fenotípicamente un total de 138 E. coli que provenían de muestras clínicas humanas (n= 48, 38.4%), carne de mercado (n=66, 52.8%) y aves de vida libre (n=24, 19.2%). Entre estos la presencia total de E. coli productoras de BLEE fue de 74 cepas con 70.8% (34/48) en aislados clínicos, 54.6% (36/66) en carnes de mercado y 16.7% (4/24) en aves silvestres de vida libre. Los niveles de resistencia para E. coli productoras de BLEE aislados de muestras clínicas humanas fue 88.2% (30/34) para ácido nalidíxico, ciprofloxacino y levofloxacino, 79.4% (27/34) cotrimoxazol, 55.9% (19/34) tobramicina y 14.7% (5/34) colistina. En carne de mercado, el 97% (35/36) para tetraciclinas, 94% (34/36) para ácido nalidíxico, ciprofloxacino y levofloxacino, 86% (31/36) cotrimoxazol, 78% (28/36) tobramicina y 47% (17/36) colistina. En aves silvestres, solo las muestras de heces frescas de Gallinazo Cabeza negra (Coragyps atratus) y Cormorán Neotropical (Phalacrocorax brasilianus) presentaron resistencia al 100% (4/4) ácido nalidíxico, ciprofloxacino y levofloxacino, 50% (2/4) gentamicina, 100% (4/4) para tobramicina, tetraciclina y cotrimoxazol. Se observó un patrón de Multirresistencia (MDR) en los diferentes tipos de muestras. Entre los aislados de E. coli BLEE se reportó con mayor frecuencia la variante CTX-M-55 para los tres orígenes. En humanos y carnes de mercado se detectó la variante CTX-M-15, y, finalmente solo en humanos se detectó la variante CTX-M-27. Además, se detectaron las variantes CTX-M-65 y SHV-27 solo en carne de pollo. No se observó relación clonal entre las E. coli productoras de BLEE del estudio, mostrando una elevada diversidad clonal de los aislados. | |
dc.description.abstract | The aim of this study was to identify, determinate the levels of antimicrobial resistance and clonality of extended-spectrum β- lactamase (ESBL) in E. coli from three different origins: Human clinic, Market meat and free-living wild birds in the south of Lima. A total of 125 samples were collected, corresponding to 63 humans clinical, 21 market meat and 41 of cloacal swabs and fresh feces from free-living wildbirds. Subsequently, a total of 138 E. coli was isolated and phenotypically identified from human clinical (n=48) market meat (n=66) and free-living wild birds (n=24). Among, the presence of ESBL-producing E. coli was 74 strains with 70.8% (34/48) in clinical isolates, 54.6% (36/66) in market meat and 16.7% (4/24) in wild birds. The resistance levels for ESBL producing E. coli from clinical isolated was 88.2% (30/34) for nalidixic acid, ciprofloxacin and levofloxacin, 79.4% (27/34) for cotrimoxazole, 55.9% (19/34) for tobramycin, 14.7% (5/34) for colistin. In market meat samples was 97% (35/36) presented resistance to tetracyclines, 94% (34/36) to nalidixic acid, ciprofloxacin and levofloxacin, 86% (31/36) cotrimoxazole, 78% (28/36) tobramycin and 47% (17/36) for colistin. Finally, in wild birds only the samples of fresh feces of Black Vulture (Coragyps atratus) and Neotropical Cormorant (Phalacrocorax brasilianus) presented resistance to 100% (4/4) nalidixic acid, ciprofloxacin and levofloxacin, 50% (2/4) gentamicin, 100% (4/4) tobramycin, tetracycline and cotrimoxazole. A Multidrug Resistance (MDR) pattern was observed in the different types of samples. Among the ESBL-producing E. coli isolates, the CTX-M-55 variant was reported most frequently reported for the three origins. In humans and market meat, the CTX-M-15 variant was detected, while the CTX-M 27 variant was detected only in humans. In addition, the CTX-M-65 and SHV-27 variants, were detected in chicken meat. No clonal relationship was observed between the ESBL- producing E. coli in the study, showing high clonal diversity of the isolates. | |
dc.language | spa | |
dc.publisher | Universidad Peruana Cayetano Heredia | |
dc.publisher | PE | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | E. coli | |
dc.subject | Resistencia Antibiótica | |
dc.subject | β-lactamasa de Espectro Extendido | |
dc.subject | blaCTX-M | |
dc.subject | Una Salud | |
dc.title | Estudio exploratorio de la presencia de Escherichia coli productoras de β-lactamasas de espectro extendido aisladas de muestras clínicas de humanos, carne expendida en mercados y aves silvestres de la zona sur de Lima | |
dc.type | info:eu-repo/semantics/masterThesis | |