Multiple Independent Introductions of Plasmodium Falciparum in South America

dc.creatorYalcindag, Erhan
dc.creatorElguero, Eric
dc.creatorArnathau, Céline
dc.creatorDurand, Patrick
dc.creatorAkiana, Jean
dc.creatorAnderson, Timothy J
dc.creatorAubouy, Agnes
dc.creatorBalloux, François
dc.creatorBesnard, Patrick
dc.creatorBogreau, Hervé
dc.creatorCarnevale, Pierre
dc.creatorD'Alessandro, Umberto
dc.creatorFontenille, Didier
dc.creatorGamboa, Dionicia
dc.creatorJombart, Thibaut
dc.creatorLe Mire, Jacques
dc.creatorLeroy, Eric
dc.creatorMaestre Buitrago, Amanda Elena
dc.creatorMayxay, Mayfong
dc.creatorMénard, Didier
dc.creatorMusset, Lise
dc.creatorNewton, Paul N.
dc.creatorNkoghé, Dieudonné
dc.creatorNoya, Oscar
dc.creatorOllomo, Benjamin
dc.creatorRogier, Christophe
dc.creatorVeron, Vincent
dc.creatorWide, Albina
dc.creatorZakeri, Sedigheh
dc.creatorCarme, Bernard
dc.creatorLegrand, Eric
dc.creatorChevillon, Christine
dc.creatorAyala Pereda, Francisco José
dc.creatorRenaud, François
dc.creatorPrugnollea, Franck
dc.date2023-04-18T16:46:05Z
dc.date2023-04-18T16:46:05Z
dc.date2012
dc.date.accessioned2024-04-23T18:13:25Z
dc.date.available2024-04-23T18:13:25Z
dc.identifierYalcindag E, Elguero E, Arnathau C, Durand P, Akiana J, Anderson TJ, Aubouy A, Balloux F, Besnard P, Bogreau H, Carnevale P, D'Alessandro U, Fontenille D, Gamboa D, Jombart T, Le Mire J, Leroy E, Maestre A, Mayxay M, Ménard D, Musset L, Newton PN, Nkoghé D, Noya O, Ollomo B, Rogier C, Veron V, Wide A, Zakeri S, Carme B, Legrand E, Chevillon C, Ayala FJ, Renaud F, Prugnolle F. Multiple independent introductions of Plasmodium falciparum in South America. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):511-6. doi: 10.1073/pnas.1119058109.
dc.identifier0027-8424
dc.identifierhttps://hdl.handle.net/10495/34714
dc.identifier10.1073/pnas.1119058109
dc.identifier091-6490
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9230554
dc.descriptionABSTRACT: The origin of Plasmodium falciparum in South America is controversial. Some studies suggest a recent introduction during the European colonizations and the transatlantic slave trade. Other evidence—archeological and genetic—suggests a much older origin. We collected and analyzed P. falciparum isolates from different regions of the world, encompassing the distribution range of the parasite, including populations from sub-Saharan Africa, the Middle East, Southeast Asia, and South America. Analyses of microsatellite and SNP polymorphisms show that the populations of P. falciparum in South America are subdivided in two main genetic clusters (northern and southern). Phylogenetic analyses, as well as Approximate Bayesian Computation methods suggest independent introductions of the two clusters from African sources. Our estimates of divergence time between the South American populations and their likely sources favor a likely introduction from Africa during the transatlantic slave trade.
dc.descriptionCOL0047449
dc.format6
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherNational Academy of Sciences
dc.publisherSalud y Comunidad
dc.publisherWashington, Estados Unidos
dc.relationProc. Natl. Acad. Sci. U. S. A.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHuman Migration
dc.subjectMigración Humana
dc.subjectGenetic Variation
dc.subjectVariación Genética
dc.subjectMalaria, Falciparum
dc.subjectMalaria Falciparum
dc.subjectPlasmodium Falciparum
dc.titleMultiple Independent Introductions of Plasmodium Falciparum in South America
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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