Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection

dc.creatorMontaño Mendoza, Vicky Margarita
dc.creatorMéndez Cortina, Yorjagis Andrés
dc.creatorRodríguez Perea, Ana Lucia
dc.creatorFernández Geysson, Javier
dc.creatorRugeles López, María Teresa
dc.creatorVelilla Hernández, Paula Andrea
dc.creatorCardona Maya, Walter Dario
dc.date2023-06-07T15:52:43Z
dc.date2023-06-07T15:52:43Z
dc.date2023
dc.date.accessioned2024-04-23T18:00:42Z
dc.date.available2024-04-23T18:00:42Z
dc.identifierMontaño Mendoza VM, Mendez Cortina YA, Rodríguez-Perea AL, Fernandez GJ, Rugeles MT, Velilla Hernandez PA, Cardona Maya WD. Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection. Heliyon. 2023 Jan;9(1):e13045. doi: 10.1016/j.heliyon.2023.e13045. Epub 2023 Jan 18. PMID: 36685472; PMCID: PMC9847338.
dc.identifier2405-8440
dc.identifierhttps://hdl.handle.net/10495/35334
dc.identifier10.1016/j.heliyon.2023.e13045.
dc.identifier2405-8440
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9230241
dc.descriptionABSTRACT: For the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, clinical manifestations are broad and highly heterogeneous for both sexes. We aimed to determine how biological sex and age impact immune gene expression, particularly influencing the humoral neutralizing antibody (NAb) response and the cytokine production in coronavirus disease 2019 (COVID-19) subjects. The immune gene expression, according to biological sex and age, was assessed using the genome wide expression profile of blood proteins from healthy individuals using the Genotype Tissue Expression (GTEx) database. Moreover, anti-SARS-CoV-2 neutralizing antibody titers and cytokine levels were determined in blood samples from 141 COVID-19 individuals from Medellín, Colombia. Among subjects with COVID-19, males had statistically significantly higher median NAb titers and serum concentrations of interleukin-6 and CC chemokine ligand 3 than females. Overall, our findings point out a more robust innate immune response in women that could help recognize and restrain the virus faster than in men.
dc.descriptionCOL0007631
dc.descriptionCOL0012444
dc.descriptionCOL0007865
dc.format11
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.publisherBiología y Control de Enfermedades Infecciosas
dc.publisherGrupo Reproducción
dc.publisherInmunovirología
dc.publisherUnipluriversidad
dc.publisherLondres, Inglaterra
dc.relationHeliyon
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSARS-CoV-2
dc.subjectSíndrome Respiratorio Agudo Grave
dc.subjectSevere Acute Respiratory Syndrome
dc.subjectGenes
dc.subjectAlergia e Inmunología
dc.subjectAllergy and Immunology
dc.subjectAnticuerpos Neutralizantes
dc.subjectAntibodies, Neutralizing
dc.subjectCitocinas
dc.subjectCytokines
dc.subjectDistribución por Edad y Sexo
dc.subjectAge and Sex Distribution
dc.titleBiological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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