Clinical and Laboratory Profile of Persons Living with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome and Histoplasmosis from a Colombian Hospital

dc.creatorCáceres Contreras, Diego Hernando
dc.creatorTobón Orozco, Angela María
dc.creatorAhlquist Cleveland, Angela
dc.creatorScheel, Christina M.
dc.creatorBerbesi Fernández, Dedsy Yajaira
dc.creatorOchoa Acosta, Jesús Ernesto
dc.creatorRestrepo Moreno, Ángela
dc.creatorBrandt, Mary E.
dc.creatorChiller, Tom
dc.creatorGómez Giraldo, Beatriz Lucía
dc.date2023-07-25T02:02:11Z
dc.date2023-07-25T02:02:11Z
dc.date2016
dc.date.accessioned2024-04-23T17:52:37Z
dc.date.available2024-04-23T17:52:37Z
dc.identifierCaceres DH, Tobón AM, Cleveland AA, Scheel CM, Berbesi DY, Ochoa J, Restrepo A, Brandt ME, Chiller T, Gómez BL. Clinical and Laboratory Profile of Persons Living with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome and Histoplasmosis from a Colombian Hospital. Am J Trop Med Hyg. 2016 Oct 5;95(4):918-924. doi: 10.4269/ajtmh.15-0837
dc.identifier0002-9637
dc.identifierhttps://hdl.handle.net/10495/35999
dc.identifier10.4269/ajtmh.15-0837
dc.identifier1476-1645
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9230008
dc.descriptionABSTRACT: Histoplasmosis is common among persons living with human immunodeficiency virus/acquired immune deficiency syndrome (PLWHA) in Latin America, but its diagnosis is difficult and often nonspecific. We conducted prospective screening for histoplasmosis among PLWHA with signs or symptoms suggesting progressive disseminated histoplasmosis (PDH) and hospitalized in Hospital La María in Medellín, Colombia. The study's aim was to obtain a clinical and laboratory profile of PLWHA with PDH. During 3 years (May 2008 to August 2011), we identified 89 PLWHA hospitalized with symptoms suggestive of PDH, of whom 45 (51%) had histoplasmosis. We observed tuberculosis (TB) coinfection in a large proportion of patients with PDH (35%), so all analyses were performed adjusting for this coinfection and, alternatively, excluding histoplasmosis patients with TB. Results showed that the patients with PDH were more likely to have Karnofsky score ≤ 30 (prevalence ratio [PR] = 1.98, 95% confidence interval [CI] = 0.97-4.06), liver compromised with hepatomegaly and/or splenomegaly (PR = 1.77, CI = 1.03-3.06) and elevation in serum of alanine aminotransferase and aspartate aminotransferase to values > 40 mU/mL (PR = 2.06, CI = 1.09-3.88 and PR = 1.53, CI = 0.99-2.35, respectively). Using multiple correspondence analyses, we identified in patients with PDH a profile characterized by the presence of constitutional symptoms, namely weight loss and Karnofsky classification ≤ 30, gastrointestinal manifestations with alteration of liver enzymes and hepatosplenomegaly and/or splenomegaly, skin lesions, and hematological alterations. Study of the profiles is no substitute for laboratory diagnostics, but identifying clinical and laboratory indicators of PLWHA with PDH should allow development of strategies for reducing the time to diagnosis and thus mortality caused by Histoplasma capsulatum.
dc.descriptionCOL0004362
dc.descriptionCOL0013709
dc.format7
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.publisherEpidemiología
dc.publisherMicología Médica y Experimental
dc.publisherBaltimore, Estados Unidos
dc.relationAm. J. Trop. Med. Hyg.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectSíndrome de Inmunodeficiencia Adquirida
dc.subjectAcquired Immunodeficiency Syndrome
dc.subjectVIH
dc.subjectHIV
dc.subjectHistoplasmosis
dc.titleClinical and Laboratory Profile of Persons Living with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome and Histoplasmosis from a Colombian Hospital
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


Este ítem pertenece a la siguiente institución