| dc.creator | Robledo Restrepo, Sara María | |
| dc.creator | Martínez Martínez, Alejandro | |
| dc.creator | Galeano Jaramillo, Elkin de Jesús | |
| dc.creator | Surmay Surmay, Verónica | |
| dc.creator | Pastrana Restrepo, Manuel Humberto | |
| dc.date | 2023-04-07T17:52:19Z | |
| dc.date | 2023-04-07T17:52:19Z | |
| dc.date | 2019 | |
| dc.date.accessioned | 2024-04-23T17:49:49Z | |
| dc.date.available | 2024-04-23T17:49:49Z | |
| dc.identifier | 0103-5053 | |
| dc.identifier | https://hdl.handle.net/10495/34533 | |
| dc.identifier | 10.21577/0103-5053.20180160 | |
| dc.identifier | 1678-4790 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9229948 | |
| dc.description | ABSTRACT: Novel iodotyramides with para-substituted benzoic acids were synthesized via electrophilic aromatic substitutions and amide coupling via N,N’-diisopropylcarbodiimide (DIC) in dimethylformamide (DMF). All derivatives were in vitro screened against U-937 macrophages and Plasmodium falciparum, Leishmania panamensis and Trypanosoma cruzi protozoan parasites. The hemolytic activity was evaluated on human red blood cells (RBC). Compounds N-(4-hydroxy-3,5-diiodophenethyl)-4-methylbenzamide and N-(3,5-diiodo4-methoxyphenethyl)-4-methoxybenzamide were the most active against L. panamensis with an effective concentration 50 (EC50) of 17.9 and 17.5 μg mL-1, respectively; while compounds N-(3,5-diiodo-4-methoxyphenethyl)-4-methylbenzamide and N-(3,5-diiodo-4-methoxyphenethyl)- 4-methoxybenzamide were the most active for T. cruzi with EC50 values of 23.75 and 6.19 μg mL-1 , respectively. In contrast, all derivatives showed high activity against P. falciparum with EC50 < 25 μg mL-1, except compound N-(4-hydroxy-3,5-diiodophenethyl)-benzamide. No compound was hemolytic over RBC. This report represents the importance of novel iodotyramides as anti-parasites agents. | |
| dc.description | COL0015099 | |
| dc.description | COL0015043 | |
| dc.format | 8 | |
| dc.format | application/pdf | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Sociedade Brasileira de Química | |
| dc.publisher | Productos Naturales Marinos | |
| dc.publisher | Programa de Estudio y Control de Enfermedades Tropicales (PECET) | |
| dc.publisher | São Paulo, Brasil | |
| dc.relation | J. Braz. Chem. Soc. | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/2.5/co/ | |
| dc.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Anticuerpos Antiprotozoarios | |
| dc.subject | Antibodies, Protozoan | |
| dc.subject | Leishmania guyanensis | |
| dc.subject | Plasmodium falciparum | |
| dc.subject | Trypanosoma cruzi | |
| dc.subject | Citotoxicidad | |
| dc.subject | Cytotoxicity | |
| dc.subject | http://aims.fao.org/aos/agrovoc/c_34251 | |
| dc.title | Anti-parasite activity of novel 3,5-diiodophenethyl-benzimides | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.type | https://purl.org/redcol/resource_type/ART | |
| dc.type | Artículo de investigación | |
