Life-course Social Position, Obesity and Diabetes Risk in the EPIC-Spain Cohort

dc.creatorColorado Yohar, Sandra Milena
dc.creatorCirera, Lluís
dc.creatorHuerta, José María
dc.creatorChirlaque, María Dolores
dc.creatorMolina Montes, Esther
dc.creatorMiren Altzibar, Jone
dc.creatorArdanaz, Eva
dc.creatorGavrila, Diana
dc.creatorBarricarte, Aurelio
dc.creatorArriola, Larraitz
dc.creatorQuirós, José R.
dc.creatorSánchez Cantalejo, Emilio
dc.creatorSánchez, María José
dc.creatorAgudo, Antonio
dc.creatorNavarro, Carmen
dc.date2023-06-14T19:23:45Z
dc.date2023-06-14T19:23:45Z
dc.date2016
dc.date.accessioned2024-04-23T17:49:45Z
dc.date.available2024-04-23T17:49:45Z
dc.identifierCirera L, Huerta JM, Chirlaque MD, Molina-Montes E, Altzibar JM, Ardanaz E, et al. Life-course social position, obesity and diabetes risk in the EPIC-Spain Cohort. Eur J Public Health [Internet]. 1 de junio de 2016;26(3):439-45. Disponible en: https://doi.org/10.1093/eurpub/ckv218
dc.identifier1101-1262
dc.identifierhttps://hdl.handle.net/10495/35498
dc.identifier10.1093/eurpub/ckv218
dc.identifier1464-360X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9229944
dc.descriptionABSTRACT: Background: The literature has consistently shown that extreme social-economic groups predicted type 2 diabetes mellitus (T2D), rather than summarising the social gradient throughout all society stratification. Body mass index (BMI) was established as the principal mediator, with little support for other anthropometries. Our aim was to investigate an individual life-course social position (LiSoP) gradient and its mediators with T2D risk in the EPICSpain cohort. Methods: 36 296 participants (62% women), mostly aged 30–65 years, and free of T2D at baseline (1992–1996) were followed up for a mean of 12.1 years. A combined score of paternal occupation in childhood and own adult education assessed individual life-course social risk accumulation. Hazard ratios of T2D were estimated using Cox regression, stratifying by centre and age, and adjusting for different explanatory models, including anthropometric indices; dietary history; smoking and physical activity lifestyles; and clinical information. Results: Final models evidenced significant risks in excess of 63% for middle and 90% for lower classes of LiSoP in men; and of 104 and 126%, respectively, in women. Concurrently, LiSoP presented significant social gradients for T2D risk (P < 0.01) in both sexes. Waist circumference (WC) accounted for most of the risk excess in women, and BMI and WC in men. Conclusions: LiSoP gradient was related to T2D risk in Spanish men and women. WC mostly explained the relationship in both genders, together with BMI in men, yet LiSoP retained an independent effect in final models.
dc.descriptionCOL0003249
dc.format7
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.publisherDemografía y Salud
dc.publisherOxford, Inglaterra
dc.relationEur. J. Public. Health.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDiabetes Mellitus Tipo 2
dc.subjectBody Mass Index
dc.subjectÍndice de Masa Corporal
dc.subjectAnthropometry
dc.subjectAntropometría
dc.subjectSocial Class
dc.subjectClase Social
dc.subjectComorbidity
dc.subjectComorbilidad
dc.subjectSocioeconomic Factors
dc.subjectFactores Socioeconómicos
dc.subjectObesity - epidemiology
dc.subjectObesidad - epidemiología
dc.titleLife-course Social Position, Obesity and Diabetes Risk in the EPIC-Spain Cohort
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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