Interactive effects of mechanical ventilation, inhaled nitric oxide and oxidative stress in acute lung injury

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRonchi, Carlos Fernando
dc.creatorFerreira, Ana Lúcia dos Anjos
dc.creatorCampos, Fabio Joly
dc.creatorKurokawa, Cilmery Suemi
dc.creatorCarpi, Mario Ferreira
dc.creatorMoraes, Marcos Aurelio
dc.creatorBonatto, Rossano César
dc.creatorYeum, Kyung-Jin
dc.creatorFioretto, José Roberto
dc.date2014-12-03T13:10:30Z
dc.date2016-10-25T20:10:38Z
dc.date2014-12-03T13:10:30Z
dc.date2016-10-25T20:10:38Z
dc.date2014-01-01
dc.date.accessioned2017-04-06T06:20:11Z
dc.date.available2017-04-06T06:20:11Z
dc.identifierRespiratory Physiology & Neurobiology. Amsterdam: Elsevier Science Bv, v. 190, n. 1, p. 118-123, 2014.
dc.identifier1569-9048
dc.identifierhttp://hdl.handle.net/11449/112199
dc.identifierhttp://acervodigital.unesp.br/handle/11449/112199
dc.identifier10.1016/j.resp.2013.10.008
dc.identifierWOS:000329004900017
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2013.10.008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/922965
dc.descriptionTo compare conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFOV), with/without inhaled nitric oxide (iNO), for oxygenation, inflammation, antioxidant/oxidative stress status, and DNA damage in a model of acute lung injury (ALI). Lung injury was induced by tracheal infusion of warm saline. Rabbits were ventilated at F-IO2 1.0 and randomly assigned to one of five groups. Overall antioxidant defense/oxidative stress was assessed by total antioxidant performance assay, and DNA damage by comet assay. Ventilatory and hemodynamic parameters were recorded every 30 min for 4 h. ALI groups showed worse oxygenation than controls after lung injury. After 4 h of mechanical ventilation, HFOV groups presented significant improvements in oxygenation. HFOV with and without iNO, and CMV with iNO showed significantly increased antioxidant defense and reduced DNA damage than CMV without iNO. Inhaled nitric oxide did not beneficially affect HFOV in relation to antioxidant defense/oxidative stress and pulmonary DNA damage. Overall, lung injury was reduced using HFOV or CMV with iNO. (C) 2013 Elsevier B.V. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationRespiratory Physiology & Neurobiology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectConventional mechanical ventilation
dc.subjectDNA damage
dc.subjectHigh-frequency oscillatory ventilation
dc.subjectInhaled nitric oxide
dc.subjectPulmonary oxidative stress
dc.titleInteractive effects of mechanical ventilation, inhaled nitric oxide and oxidative stress in acute lung injury
dc.typeOtro


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