Polymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus

dc.creatorEscobar Chaves, Elkin Leandro
dc.creatorAcín Martínez, Sergio
dc.creatorMuñoz Herrera, Diana Lorena
dc.creatorFernández Culma, Maritza
dc.creatorEcheverri, Alexandra
dc.creatorEcheverri López, Luis Fernando
dc.creatorOrozco Holguín, Jahir
dc.creatorBalcázar Morales, Norman
dc.date2023-02-16T14:42:36Z
dc.date2023-02-16T14:42:36Z
dc.date2023
dc.date.accessioned2024-04-23T17:38:50Z
dc.date.available2024-04-23T17:38:50Z
dc.identifier1773-2247
dc.identifierhttps://hdl.handle.net/10495/33500
dc.identifier10.1016/j.jddst.2023.104264
dc.identifier2588-8943
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9229642
dc.descriptionABSTRACT: Triterpene-enriched fractions (TFs) from Eucalyptus tereticornis demonstrated efficiency when administered intraperitoneally in diet-induced obesity (DIO) mouse model to treat obesity-related type 2 diabetes mellitus (T2DM); however, its oral administration has not yet led to satisfactory results. In this context, we developed a polymeric nanoformulation to transport TFs orally in DIO mice and control obesity and T2DM effects. We encapsulated TFs in a polylactic-co-glycolic acid-based nanocarrier, physicochemically characterized the nanocarriers, and evaluated TFs in-vitro release kinetics, in-vivo metabolic biomarkers, and released triterpenes in a simulated in-vitro human gastrointestinal model. The nanoformulation showed a TFs release of 80% in the first 6h in-vitro, and the in-vivo assay demonstrated a decrease in mice weight, glycaemia, glucose, and insulin intolerance. Finally, triterpenes released up to 75% in the simulated in-vitro human intestine. These results open the way for developing new strategies of therapeutic agents with natural products to control obesity and T2DM.
dc.descriptionCOL0006723
dc.descriptionCOL0015339
dc.format11
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.publisherGenética Molecular (GENMOL)
dc.publisherQuímica Orgánica de Productos Naturales
dc.publisherParís, Francia
dc.relationJ. Drug Deliv. Sci. Technol.
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPolímeros
dc.subjectPolymers
dc.subjectObesidad
dc.subjectObesity
dc.subjectInflamación
dc.subjectInflammation
dc.subjectTriterpenos
dc.subjectTriterpenes
dc.subjectRatones
dc.subjectMice
dc.subjectDiabetes Mellitus Tipo 2
dc.subjectDiabetes Mellitus, Type 2
dc.subjectEucalyptus tereticornis
dc.titlePolymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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