| dc.creator | González Franco, Juliana | |
| dc.creator | Caicedo Espinosa, Javier Eduardo | |
| dc.creator | Cardona Tobón, Carolina | |
| dc.creator | Jaramillo Jara, Natalia | |
| dc.creator | Aguilar Molina, Oswaldo | |
| dc.creator | Jaimes Barragán, Fabian | |
| dc.creator | Saldarriaga Giraldo, Clara Ines | |
| dc.date | 2023-07-08T00:30:07Z | |
| dc.date | 2023-07-08T00:30:07Z | |
| dc.date | 2023 | |
| dc.date.accessioned | 2024-04-23T17:38:49Z | |
| dc.date.available | 2024-04-23T17:38:49Z | |
| dc.identifier | https://hdl.handle.net/10495/35809 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9229640 | |
| dc.description | ABSTRACT: Introduction: The evidence for the pharmacological treatment of heart failure is based on randomized clinical trials with strict inclusion and exclusion criteria. Objectives: To evaluate the proportion of patients with chronic heart failure from an outpatient cohort who would be eligible for the trials DAPA-HF, EMPEROR-reduced, and PARADIGM-HF, and to determine potential differences between study populations.
Methods: Through revision of medical records, we calculated the proportion of patients who would have been eligible for each study and evaluated the incidence of heart failure hospitalizations and all-cause mortality during this period.
Results: A total of 446 patients were included in the cohort. Approximately 75% would be ineligible for the
trials, mainly because of their comorbidities. Ineligible patients had a higher all-cause mortality, but a similar
incidence of hospitalization.
Conclusion: Approximately 1 in 4 patients from a heart failure clinic in Medellin, Colombia would meet the
eligibility criteria for the DAPA-HF, EMPEROR-reduced, and PARADIGM-HF trials. These findings highlight the need to complement randomized clinical trials with real-world data. | |
| dc.format | 36 | |
| dc.format | application/pdf | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Medellín, Colombia | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.rights | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Insuficiencia cardiaca | |
| dc.subject | Heart failure | |
| dc.subject | Ensayos clínicos controlados aleatorios como asunto | |
| dc.subject | Randomized controlled trials as topic | |
| dc.subject | Determinación de la elegibilidad | |
| dc.subject | Eligibility determination | |
| dc.subject | https://id.nlm.nih.gov/mesh/D006333 | |
| dc.subject | https://id.nlm.nih.gov/mesh/D016032 | |
| dc.subject | https://id.nlm.nih.gov/mesh/D004608 | |
| dc.title | Application of eligibility criteria from DAPA-HF, EMPEROR-Reduced, and PARADIGM-HF trials to a population with heart failure with reduced ejection fraction at a specialized cardiology Clinic in Medellin, Colombia: A Retrospective Cohort Study | |
| dc.type | info:eu-repo/semantics/other | |
| dc.type | info:eu-repo/semantics/draft | |
| dc.type | http://purl.org/coar/resource_type/c_46ec | |
| dc.type | http://purl.org/redcol/resource_type/COther | |
| dc.type | Tesis/Trabajo de grado - Monografía - Especialización | |
