Assessment of the Origins and Spread of Putative Resistance-Conferring Mutations in Plasmodium vivax Dihydropteroate Synthase

dc.creatorMaestre Buitrago, Amanda Elena
dc.creatorHawkins, Vivian N.
dc.creatorSuzuki, Stephanie M.
dc.creatorRungsihirunrat, Kanchana
dc.creatorHapuarachchi, Hapuarachchige C.
dc.creatorNa-Bangchang, Kesara
dc.creatorHopkins Sibley, Carol
dc.date2023-03-30T22:13:26Z
dc.date2023-03-30T22:13:26Z
dc.date2009
dc.date.accessioned2024-04-23T14:19:08Z
dc.date.available2024-04-23T14:19:08Z
dc.identifier0002-9637
dc.identifierhttps://hdl.handle.net/10495/34373
dc.identifier10.4269/ajtmh.2009.81.348
dc.identifier1476-1645
dc.identifierhttps://doi.org/10.4269/ajtmh.2009.81.348
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9229484
dc.descriptionABSTRACT: Infection with Plasmodium vivax is usually treated with chloroquine, but parasites are often exposed inadvertently to sulfadoxine-pyrimethamine. To infer patterns of selection and spread of resistant parasites in natural populations, we determined haplotypes of P. vivax dihydropteroate synthase ( dhps ) alleles that could confer resistance to sulfadoxine. We amplified the P. vivax pyrophosphokinase ( pppk )– dhps region and its flanking intergenic regions from 92 contemporary global isolates. Introns and exons of pppk-dhps were highly polymorphic, as were the flanking intergenic regions. Eighteen haplotypes were associated with wild-type alleles, but several different putatively sulfadoxine-resistant alleles have arisen in areas of intensive sulfadoxine-pyrimethamine use. Even when they encoded changes to the same amino acid, these mutant alleles were associated with multiple different haplotypes. Two main conclusions can be drawn from these data. First, dhps alleles resistant to sulfadoxine have arisen multiple times under drug pressure. Second, there has been convergent evolution of a variety of alleles that could confer resistance to sulfa drugs.
dc.descriptionCOL0047449
dc.format8
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.publisherSalud y Comunidad
dc.publisherBaltimore, Estados Unidos
dc.relationAm. J. Trop. Med. Hyg.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectDNA, Intergenic
dc.subjectADN Intergénico
dc.subjectMutation
dc.subjectMutación
dc.subjectPlasmodium vivax
dc.subjectAlleles
dc.subjectAlelos
dc.subjectAmino Acids
dc.subjectAminoácidos
dc.subjectDihydropteroate Synthase
dc.subjectDihidropteroato Sintasa
dc.titleAssessment of the Origins and Spread of Putative Resistance-Conferring Mutations in Plasmodium vivax Dihydropteroate Synthase
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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