Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever

dc.creatorRodas González, Juan David
dc.creatorZapata Jiménez, Juan Carlos
dc.creatorPauza, C. David
dc.creatorLukashevich, Igor S
dc.creatorSalvato, Maria S.
dc.creatorDjavani, Mahmoud M.
dc.creatorGarcia, Cybele
dc.creatorMoshkoff, Dmitry
dc.creatorBryant, Joseph
dc.creatorAteh, Eugene
dc.date2023-03-12T17:22:30Z
dc.date2023-03-12T17:22:30Z
dc.date2011
dc.date.accessioned2024-04-23T14:15:48Z
dc.date.available2024-04-23T14:15:48Z
dc.identifierZapata JC, Pauza CD, Djavani MM, Rodas JD, Moshkoff D, Bryant J, Ateh E, Garcia C, Lukashevich IS, Salvato MS. Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever. Antiviral Res. 2011 Nov;92(2):125-38. doi: 10.1016/j.antiviral.2011.07.015.
dc.identifier0166-3542
dc.identifierhttps://hdl.handle.net/10495/33937
dc.identifier10.1016/j.antiviral.2011.07.015
dc.identifier1872-9096
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9229377
dc.descriptionABSTRACT: Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human beings. LCMV is considerably more benign for human beings than Lassa virus, however certain strains, like the LCMV-WE strain, can cause severe disease when the virus is delivered as a high-dose inoculum. Here we describe a rhesus macaque model for Lassa fever that employs a virulent strain of LCMV. Since LASV must be studied within Biosafety Level-4 (BSL-4) facilities, the LCMV-infected macaque model has the advantage that it can be used at BSL-3. LCMV-induced disease is rarely as severe as other VHF, but it is similar in cases where vascular leakage leads to lethal systemic failure. The LCMV- infected macaque has been valuable for describing the course of disease with differing viral strains, doses and routes of infection. By monitoring system-wide changes in physiology and gene expression in a controlled experimental setting, it is possible to identify events that are pathognomonic for developing VHF and potential treatment targets.
dc.descriptionCOL0001262
dc.format33
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherInternational Society for Antiviral Research
dc.publisherElsevier
dc.publisherCENTAURO
dc.publisherÁmsterdam, Países Bajos
dc.relationAntiviral. Res.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectInfecciones por Arenaviridae
dc.subjectArenaviridae Infections
dc.subjectModelos Animales de Enfermedad
dc.subjectDisease Models, Animal
dc.subjectFiebre de Lassa
dc.subjectLassa Fever
dc.subjectVirus de la Coriomeningitis Linfocítica
dc.subjectLymphocytic choriomeningitis virus
dc.subjectMacaca mulatta
dc.titleLymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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