Microsatellites Provide Evidence for Y Chromosome Diversity Among the Founders of the New World

dc.creatorRuiz Linares, Andrés
dc.creatorOrtíz Barrientos, Daniel
dc.creatorFigueroa, Mauricio
dc.creatorMesa, Natalia
dc.creatorMúnera, Juan Guillermo
dc.creatorBedoya, Gabriel
dc.creatorVélez Bernal, Iván Darío
dc.creatorGarcía Moreno, Luis Fernando
dc.creatorPérez Lezaun, Anna
dc.creatorBertranpetit, Jaume
dc.creatorFeldman, Marcus William
dc.creatorGoldstei, David Benjamin
dc.date2023-04-18T16:11:06Z
dc.date2023-04-18T16:11:06Z
dc.date1999
dc.date.accessioned2024-04-23T14:13:22Z
dc.date.available2024-04-23T14:13:22Z
dc.identifierRuiz-Linares A, Ortíz-Barrientos D, Figueroa M, Mesa N, Múnera JG, Bedoya G, Vélez ID, García LF, Pérez-Lezaun A, Bertranpetit J, Feldman MW, Goldstein DB. Microsatellites provide evidence for Y chromosome diversity among the founders of the New World. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6312-7. doi: 10.1073/pnas.96.11.6312.
dc.identifier0027-8424
dc.identifierhttps://hdl.handle.net/10495/34710
dc.identifier10.1073/pnas.96.11.6312
dc.identifier091-6490
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9229276
dc.descriptionABSTRACT: Recently, Y chromosome markers have begun to be used to study Native American origins. Available data have been interpreted as indicating that the colonizers of the New World carried a single founder haplotype. However, these early studies have been based on a few, mostly complex polymorphisms of insufficient resolution to determine whether observed diversity stems from admixture or diversity among the colonizers. Because the interpretation of Y chromosomal variation in the New World depends on founding diversity, it is important to develop marker systems with finer resolution. Here we evaluate the hypothesis of a single-founder Y haplotype for Amerinds by using 11 Y-specific markers in five Colombian Amerind populations. Two of these markers (DYS271, DYS287) are reliable indicators of admixture and detected three non-Amerind chromosomes in our sample. Two other markers (DYS199, M19) are single-nucleotide polymorphisms mostly restricted to Native Americans. The relatedness of chromosomes defined by these two markers was evaluated by constructing haplotypes with seven microsatellite loci (DYS388 to 394). The microsatellite backgrounds found on the two haplogroups defined by marker DYS199 demonstrate the existence of at least two Amerind founder haplotypes, one of them (carrying allele DYS199 T) largely restricted to Native Americans. The estimated age and distribution of these haplogroups places them among the founders of the New World.
dc.descriptionCOL0008639
dc.descriptionCOL0015099
dc.format6
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherNational Academy of Sciences
dc.publisherGrupo de Inmunología Celular e Inmunogenética
dc.publisherPrograma de Estudio y Control de Enfermedades Tropicales (PECET)
dc.publisherWashington, Estados Unidos
dc.relationProc. Natl. Acad. Sci. U. S. A.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMicrosatellite Repeats
dc.subjectRepeticiones de Microsatélite
dc.subjectY Chromosome
dc.subjectCromosoma Y
dc.subjectGenetic Markers
dc.subjectMarcadores Genéticos
dc.subjectAmerican Indian or Alaska Native
dc.subjectIndio Americano o Nativo de Alaska
dc.subjectHaplotypes
dc.subjectHaplotipos
dc.titleMicrosatellites Provide Evidence for Y Chromosome Diversity Among the Founders of the New World
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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