Astrocytic Modulation of Blood Brain Barrier: Perspectives on Parkinson's Disease

dc.creatorCabezas Pérez, Ricardo Julián
dc.creatorÁvila Rodríguez, Marcos Fidel
dc.creatorGonzález Santos, Janneth
dc.creatorSantos El-Bachá, Ramon
dc.creatorBáez Jurado, Eliana María
dc.creatorGarcía Segura, Luis Miguel
dc.creatorJurado Coronel, Juan Camilo
dc.creatorCapani, Francisco
dc.creatorCardona Gómez, Gloria Patricia
dc.creatorSampaio Barreto, George Emilio
dc.date2023-05-11T21:42:16Z
dc.date2023-05-11T21:42:16Z
dc.date2014
dc.date.accessioned2024-04-23T14:13:20Z
dc.date.available2024-04-23T14:13:20Z
dc.identifierCabezas R, Avila M, Gonzalez J, El-Bachá RS, Báez E, García-Segura LM, Jurado Coronel JC, Capani F, Cardona-Gomez GP, Barreto GE. Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease. Front Cell Neurosci. 2014 Aug 4;8:211. doi: 10.3389/fncel.2014.00211.
dc.identifierhttps://hdl.handle.net/10495/34984
dc.identifier10.3389/fncel.2014.00211
dc.identifier1662-5102
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9229271
dc.descriptionABSTRACT: The blood–brain barrier (BBB) is a tightly regulated interface in the Central Nervous System (CNS) that regulates the exchange of molecules in and out from the brain thus maintaining the CNS homeostasis. It is mainly composed of endothelial cells (ECs), pericytes and astrocytes that create a neurovascular unit (NVU) with the adjacent neurons. Astrocytes are essential for the formation and maintenance of the BBB by providing secreted factors that lead to the adequate association between the cells of the BBB and the formation of strong tight junctions. Under neurological disorders, such as chronic cerebral ischemia, brain trauma, Epilepsy, Alzheimer and Parkinson’s Diseases, a disruption of the BBB takes place, involving a lost in the permeability of the barrier and phenotypical changes in both the ECs and astrocytes. In this aspect, it has been established that the process of reactive gliosis is a common feature of astrocytes during BBB disruption, which has a detrimental effect on the barrier function and a subsequent damage in neuronal survival. In this review we discuss the implications of astrocyte functions in the protection of the BBB, and in the development of Parkinson’s disease (PD) and related disorders. Additionally, we highlight the current and future strategies in astrocyte protection aimed at the development of restorative therapies for the BBB in pathological conditions.
dc.descriptionCOL0010744
dc.format11
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.publisherGrupo de Neurociencias de Antioquia
dc.publisherLausana, Suiza
dc.relationFront. Cell. Neurosci.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectParkinson Disease
dc.subjectEnfermedad de Parkinson
dc.subjectEndothelial Cells
dc.subjectCélulas Endoteliales
dc.subjectAstrocytes
dc.subjectAstrocitos
dc.subjectGliosis
dc.subjectBlood-Brain Barrier
dc.subjectBarrera Hematoencefálica
dc.titleAstrocytic Modulation of Blood Brain Barrier: Perspectives on Parkinson's Disease
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_dcae04bc
dc.typehttps://purl.org/redcol/resource_type/ARTREV
dc.typeArtículo de revisión


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