The Effects of Illicit Drugs on the HIV Infected Brain

dc.creatorArango Viana, Juan Carlos
dc.creatorCrawford Anthony, Iain
dc.creatorStephens, Ben
dc.creatorSimmonds, Peter
dc.creatorBell, Jeanne Elisabeth
dc.date2023-02-17T13:47:30Z
dc.date2023-02-17T13:47:30Z
dc.date2008
dc.date.accessioned2024-04-23T14:08:13Z
dc.date.available2024-04-23T14:08:13Z
dc.identifier1093-9946
dc.identifierhttps://hdl.handle.net/10495/33514
dc.identifier1093-4715
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9229071
dc.descriptionABSTRACT: Evidence accumulating from clinical observations, neuroimaging and neuropathological studies suggests that illicit drug abuse accentuates the adverse effects of HIV on the central nervous system (CNS). Experimental investigation in cell culture models supports this conclusion. Injecting drug abuse is also a risk factor for the acquisition of HIV infection, the incidence of which continues to rise in intravenous drug users (IVDU) even in countries with access to effective therapy. In order to understand the interactions of drug abuse and HIV infection, it is necessary to examine the effects of each insult in isolation before looking for their combined effects. This review traces progress in understanding the pathogenesis of HIV related CNS disorders before the introduction of effective therapy and compares the state of our knowledge now that effective therapy has significantly modified disease progression. The additional impact of intravenous drug abuse on HIV-associated brain disease, then and now, is also reviewed. Predictions for the future are discussed, based on what is known at present and on recently emerging data.
dc.descriptionCOL0058784
dc.format14
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioscience Research Institute
dc.publisherGrupo de Investigación Clínica en Enfermedades del Niño y del Adolescente - Pediaciencias
dc.publisherTampa, Estados Unidos
dc.relationFront. Biosci.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBrain
dc.subjectEncéfalo
dc.subjectHIV
dc.subjectVIH
dc.subjectAcquired Immunodeficiency Syndrome
dc.subjectSíndrome de Inmunodeficiencia Adquirida
dc.subjectSubstance-Related Disorders
dc.subjectTrastornos Relacionados con Sustancias
dc.subjectOpiate Alkaloids
dc.subjectAlcaloides Opiáceos
dc.subjectReview
dc.subjectRevisión
dc.subjectAntiretroviral Therapy, Highly Active
dc.subjectTerapia Antirretroviral Altamente Activa
dc.titleThe Effects of Illicit Drugs on the HIV Infected Brain
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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