Dynamics of Plasmodium Falciparum Parasitemia Regarding Combined Treatment Regimens for Acute Uncomplicated Malaria, Antioquia, Colombia

dc.creatorÁlvarez Sánchez, Luis Gonzalo
dc.creatorTobón Castaño, Alberto
dc.creatorPiñeros Jiménez, Juan Gabriel
dc.creatorRíos Orrego, Alexandra Marcela
dc.creatorBlair Trujillo, Silvia
dc.date2023-03-31T16:50:23Z
dc.date2023-03-31T16:50:23Z
dc.date2010
dc.date.accessioned2024-04-23T14:08:03Z
dc.date.available2024-04-23T14:08:03Z
dc.identifier0002-9637
dc.identifierhttps://hdl.handle.net/10495/34392
dc.identifier10.4269/ajtmh.2010.09-0286
dc.identifier1476-1645
dc.identifierhttps://doi.org/10.4269/ajtmh.2010.09-0286
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9229056
dc.descriptionABSTRACT: Selecting suitable anti-malarial treatment represents one of the best tools for reducing morbidity and mortality caused by this disease. Sexual and asexual parasite dynamics were thus evaluated in patients involved in antimalarial drug efficacy studies by using combined treatment with and without artemisinin derivatives for treating uncomplicated acute Plasmodium falciparum malaria in Antioquia, Colombia. All treatment doses were supervised and administered according to patients’ weight; sexual and asexual parasitemia were evaluated during 28- or 42-days follow-up in 468 patients. Artemisinin-based combination therapy showed greater parasiticidal ability, showing a mean asexual parasitemia survival rate of one day and mean gametocyte survival rate of 1–2 days. Sexual and asexual parasitemias were eliminated more quickly and effectively in the group receiving artemisinin-based combination therapy. Adding 45 mg of primaquine to treatment with artesunate and mefloquine reduced gametocyte and asexual parasite survival by one day.
dc.descriptionCOL0007524
dc.format7
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.publisherGrupo Malaria
dc.publisherBaltimore, Estados Unidos
dc.relationAm. J. Trop. Med. Hyg.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectParasitemia
dc.subjectPlasmodium falciparum
dc.subjectMalaria
dc.subjectMalaria Falciparum
dc.subjectMalaria, Falciparum
dc.subjectAntimalarials
dc.subjectAntimaláricos
dc.subjectArtesunate
dc.subjectArtesunato
dc.subjectCombined Modality Therapy
dc.subjectTerapia Combinada
dc.subjectPrimaquine
dc.subjectPrimaquina
dc.subjectMefloquine
dc.subjectMefloquina
dc.titleDynamics of Plasmodium Falciparum Parasitemia Regarding Combined Treatment Regimens for Acute Uncomplicated Malaria, Antioquia, Colombia
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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