Epidemiological Report on the Treatment of Patients with Gestational Trophoblastic Disease in 10 Brazilian Referral Centers Results After 12 Years Since International FIGO 2000 Consensus

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBraga, Antonio
dc.creatorHartmann Uberti, Elza Maria
dc.creatorFajardo, Maria do Carmo
dc.creatorViggiano, Mauricio
dc.creatorSun, Sue Yazaki
dc.creatorGrillo, Bruno Maurizio
dc.creatorPadilha, Sergio Lunardon
dc.creatorAndrade, Jurandyr Moreira de
dc.creatorSouza, Christiani Bisinoto de
dc.creatorMadi, Jose Mauro
dc.creatorMaestá, Izildinha
dc.creatorSilveira, Eduardo
dc.date2014-12-03T13:09:15Z
dc.date2016-10-25T20:10:30Z
dc.date2014-12-03T13:09:15Z
dc.date2016-10-25T20:10:30Z
dc.date2014-05-01
dc.date.accessioned2017-04-06T06:19:35Z
dc.date.available2017-04-06T06:19:35Z
dc.identifierJournal of Reproductive Medicine. St Louis: Sci Printers & Publ Inc, v. 59, n. 5-6, p. 241-247, 2014.
dc.identifier0024-7758
dc.identifierhttp://hdl.handle.net/11449/112136
dc.identifierhttp://acervodigital.unesp.br/handle/11449/112136
dc.identifierWOS:000336419500012
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/922903
dc.descriptionOBJECTIVE: To evaluate treatment of Brazilian patients with gestational trophoblastic disease (GTD).STUDY DESIGN: A retrospective cohort study with analysis of medical reports performed in 10 Brazilian referral centers from January 2000 to December 2011.RESULTS: Of 5,250 patients 3 died (0.06%) at the time of uterine evacuation. Spontaneous remission of GTD (group G1) was observed in 4,103 cases, and 1,144 (21.8%) progressed to gestational trophoblastic neoplasia (GTN) (G2). In G1 2,716 (66.2%) had complete hydatidiform mole (HM) and 1,210, partial HM (29.5%); 3,772 patients (92.7%) recovered as noted in December 2012. In G2, of 1,118 patients treated, initial histopathological results of previous gestation were complete HM (77.5% [n = 886]), partial HM (8.8% [n = 100]), and choriocarcinoma (8.0% [n = 92]); 930 (81.3%) were low-risk, 200 (17.5%) were high-risk GTN, and 14 had placental site trophoblastic tumor (PSTT) (1.2%); cure was achieved in 1,078 cases (96.4%), but 26 patients (2.3%) died (4 low-risk [0.4%], 19 high-risk [9.5%], and 3 PSTT [21.4%]).CONCLUSION: The highest death rates were due to high-risk GTN and PSTT. Patients with molar pregnancy should be referred to a referral center for an early diagnosis and prompt treatment of GTN in order to reduce the morbidity and mortality found in advanced stages.
dc.languageeng
dc.publisherSci Printers & Publ Inc
dc.relationJournal of Reproductive Medicine
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectepidemiology
dc.subjectgestational trophoblastic disease
dc.subjectgestational trophoblastic neoplasia
dc.subjecthydatidiform mole
dc.subjectplacental site trophoblastic tumor
dc.titleEpidemiological Report on the Treatment of Patients with Gestational Trophoblastic Disease in 10 Brazilian Referral Centers Results After 12 Years Since International FIGO 2000 Consensus
dc.typeOtro


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