dc.creatorDelgado Charris, Jean Paul
dc.creatorKumara, Anoop
dc.creatorGates, Phillip B.
dc.creatorNeville, Graham
dc.creatorForge, Andrew
dc.creatorBrockes, Jeremy P.
dc.date2023-04-06T22:37:40Z
dc.date2023-04-06T22:37:40Z
dc.date2011
dc.date.accessioned2024-04-23T14:06:54Z
dc.date.available2024-04-23T14:06:54Z
dc.identifierKumar A, Delgado JP, Gates PB, Neville G, Forge A, Brockes JP. The aneurogenic limb identifies developmental cell interactions underlying vertebrate limb regeneration. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13588-93. doi: 10.1073/pnas.1108472108.
dc.identifier0027-8424
dc.identifierhttps://hdl.handle.net/10495/34481
dc.identifier10.1073/pnas.1108472108
dc.identifier1091-6490
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9229025
dc.descriptionABSTRACT: The removal of the neural tube in salamander embryos allows the development of nerve-free aneurogenic limbs. Limb regeneration is normally nerve-dependent, but the aneurogenic limb regenerates without nerves and becomes nerve-dependent after innervation. The molecular basis for these tissue interactions is unclear. Anterior Gradient (AG) protein, previously shown to rescue regeneration of denervated limbs and to act as a growth factor for cultured limb blastemal cells, is expressed throughout the larval limb epidermis and is down-regulated by innervation. In an aneurogenic limb, the level of AG protein remains high in the epidermis throughout development and regeneration, but decreases after innervation following transplantation to a normal host. Aneurogenic epidermis also shows a fivefold difference in secretory gland cells, which express AG protein. The persistently high expression of AG in the epithelial cells of an aneurogenic limb ensures that regeneration is independent of the nerve. These findings provide an explanation for this classical problem, and identify regulation of the epidermal niche by innervation as a distinctive developmental mechanism that initiates the nerve dependence of limb regeneration. The absence of this regulation during anuran limb development might suggest that it evolved in relation to limb regeneration.
dc.descriptionCOL0006769
dc.format6
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherNational Academy of Sciences
dc.publisherGenética Regeneración y Cáncer
dc.publisherWashington, Estados Unidos
dc.relationProc. Natl. Acad. Sci. U S A.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCell Communication - physiology
dc.subjectComunicación Celular - fisiología
dc.subjectEmbryo, Nonmammalian
dc.subjectEmbrión no Mamífero
dc.subjectEpidermis - physiology
dc.subjectEpidermis - fisiología
dc.subjectExtremities - growth and development
dc.subjectExtremidades - crecimiento y desarrollo
dc.subjectExtremities
dc.subjectExtremidades
dc.subjectMolecular Sequence Data
dc.subjectDatos de Secuencia Molecular
dc.subjectRegeneration
dc.subjectRegeneración
dc.subjectUrodela
dc.subjectUrodelos
dc.subjectVertebrates
dc.subjectVertebrados
dc.titleThe aneurogenic limb identifies developmental cell interactions underlying vertebrate limb regeneration
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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