A new experimental model of cigarette smoke-induced emphysema in Wistar rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorlas Heras Kozma, Rodrigo de
dc.creatorAlves, Edson Marcelino
dc.creatorBarbosa-de-Oliveira, Valter Abraao
dc.creatorSantos, Lucinéia dos
dc.creatorGuardia, Renan Cenize
dc.creatorBuzo, Henrique Vivi
dc.creatorFaria, Carolina Arruda de
dc.creatorYamashita, Camila
dc.creatorCavazzana Junior, Manzelio
dc.creatorFrei, Fernando
dc.creatorOliveira Ribeiro-Paes, Maria Jose de
dc.creatorRibeiro-Paes, Joao Tadeu
dc.date2014-12-03T13:09:11Z
dc.date2016-10-25T20:10:17Z
dc.date2014-12-03T13:09:11Z
dc.date2016-10-25T20:10:17Z
dc.date2014-01-01
dc.date.accessioned2017-04-06T06:18:43Z
dc.date.available2017-04-06T06:18:43Z
dc.identifierJornal Brasileiro de Pneumologia. Brasilia Df: Soc Brasileira Pneumologia Tisiologia, v. 40, n. 1, p. 46-54, 2014.
dc.identifier1806-3713
dc.identifierhttp://hdl.handle.net/11449/112046
dc.identifierhttp://acervodigital.unesp.br/handle/11449/112046
dc.identifierWOS:000331594000007
dc.identifierWOS000331594000007.pdf
dc.identifierhttp://dx.doi.org/10.1590/S1806-37132014000100007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/922814
dc.descriptionObjective: To describe a new murine model of cigarette smoke-induced emphysema. Methods: Twenty-four male Wistar rats were divided into two groups: the cigarette smoke group, comprising 12 rats exposed to smoke from 12 commercial filter cigarettes three times a day (a total of 36 cigarettes per day) every day for 30 weeks; and the control group, comprising 12 rats exposed to room air three times a day every day for 30 weeks. Lung function was assessed by mechanical ventilation, and emphysema was morphometrically assessed by measurement of the mean linear intercept (Lm). Results: The mean weight gain was significantly (approximately ten times) lower in the cigarette smoke group than in the control group. The Lm was 25.0% higher in the cigarette smoke group. There was a trend toward worsening of lung function parameters in the cigarette smoke group. Conclusions: The new murine model of cigarette smoke-induced emphysema and the methodology employed in the present study are effective and reproducible, representing a promising and economically viable option for use in studies investigating the pathophysiology of and therapeutic approaches to COPD.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherSoc Brasileira Pneumologia Tisiologia
dc.relationJornal Brasileiro de Pneumologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTobacco smoke pollution
dc.subjectEmphysema
dc.subjectDisease models, animal
dc.subjectEquipment and supplies
dc.titleA new experimental model of cigarette smoke-induced emphysema in Wistar rats
dc.typeOtro


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