Temporal Analysis of Lipopolysaccharide-Induced Sickness Behavior in Virgin and Lactating Female Rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorNascimento, Amanda
dc.creatorBernardi, Maria
dc.creatorPecorari, Vanessa
dc.creatorMassoco, Christina
dc.creatorFelicio, Luciano
dc.date2014-12-03T13:09:01Z
dc.date2016-10-25T20:09:50Z
dc.date2014-12-03T13:09:01Z
dc.date2016-10-25T20:09:50Z
dc.date2013-01-01
dc.date.accessioned2017-04-06T06:16:49Z
dc.date.available2017-04-06T06:16:49Z
dc.identifierNeuroimmunomodulation. Basel: Karger, v. 20, n. 6, p. 305-312, 2013.
dc.identifier1021-7401
dc.identifierhttp://hdl.handle.net/11449/111832
dc.identifierhttp://acervodigital.unesp.br/handle/11449/111832
dc.identifier10.1159/000350705
dc.identifierWOS:000325235700001
dc.identifierhttp://dx.doi.org/10.1159/000350705
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/922605
dc.descriptionObjectives: Lipopolysaccharide (LPS), an endotoxin that originates from the cell wall of Gram-negative bacteria, activates the immune system to release proinflammatory cytokines and to induce sickness behavior. The present study sought to characterize the time-dependent effects of LPS on fever, body weight, and food and water consumption in female virgin and lactating rats exposed to an LPS dose previously reported to induce sickness behavior in pregnant female rats. Methods: Virgin female Wistar rats in the estrous phase and lactating female Wistar rats on the third day of lactation received 100 mu g/kg LPS or saline solution. Tympanic temperature, body weight, and food and water consumption were assessed 0, 2, 24, 48, 72, 96, and 120 h after treatment. Results: In lactating female rats, tympanic temperature was attenuated compared with virgin females. Food consumption and body weight gain in both groups decreased, but lactating rats consumed more food than virgin rats. Water consumption increased at different time points. Conclusion: LPS exposure induced several signs of sickness behavior, including decreases in food consumption and body weight gain, and induced adipsia in both virgin and lactating female rats. Because the time course and profile of fever varied between lactating and nonlactating animals, these responses appeared to depend on the physiological state of female animals. Copyright (C) 2013 S. Karger AG, Basel
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherKarger
dc.relationNeuroimmunomodulation
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFever
dc.subjectLactating female
dc.subjectVirgin female
dc.subjectLipopolysaccharide
dc.titleTemporal Analysis of Lipopolysaccharide-Induced Sickness Behavior in Virgin and Lactating Female Rats
dc.typeOtro


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