Genomic regions harboring insecticide resistance-associated Cyp genes are enriched by transposable element fragments carrying putative transcription factor binding sites in two sibling Drosophila species

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCarareto, Claudia M. A.
dc.creatorHernandez, Eric H.
dc.creatorVieira, Cristina
dc.date2014-12-03T13:08:56Z
dc.date2016-10-25T20:09:35Z
dc.date2014-12-03T13:08:56Z
dc.date2016-10-25T20:09:35Z
dc.date2014-03-01
dc.date.accessioned2017-04-06T06:15:49Z
dc.date.available2017-04-06T06:15:49Z
dc.identifierGene. Amsterdam: Elsevier Science Bv, v. 537, n. 1, p. 93-99, 2014.
dc.identifier0378-1119
dc.identifierhttp://hdl.handle.net/11449/111730
dc.identifierhttp://acervodigital.unesp.br/handle/11449/111730
dc.identifier10.1016/j.gene.2013.11.080
dc.identifierWOS:000331428300014
dc.identifierhttp://dx.doi.org/10.1016/j.gene.2013.11.080
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/922503
dc.descriptionIn the present study, an in silico analysis was performed to identify transposable element (TE) fragments inserted in Cyps with functions associated with resistance to insecticides and developmental regulation as well as in neighboring genes in two sibling species, Drosophila melanogaster and Drosophila simulans. The Cyps associated with insecticide resistance and their neighboring non-Cyp genes have accumulated a greater number of TE fragments than the other Cyps or a random sample of genes, predominantly in the 5'-flanking regions. Most of the insertions were due to DNA transposons, with DNAREP1 fragments being the most common. These fragments carry putative binding sites for transcription factors, which reinforces the hypothesis that DNAREP1 may influence gene regulation and play a role in the adaptation of the Drosophila species. (C) 2013 Elsevier B.V. All rights reserved.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationGene
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCytochrome P450 monooxygenases
dc.subjectTransposable elements
dc.subjectDNAREP1
dc.subjectTFBS
dc.subjectGene expression regulation
dc.titleGenomic regions harboring insecticide resistance-associated Cyp genes are enriched by transposable element fragments carrying putative transcription factor binding sites in two sibling Drosophila species
dc.typeOtro


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