Genome-wide association study for feedlot average daily gain in Nellore cattle (Bos indicus)

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSantana, M. H. A.
dc.creatorUtsunomiya, Y. T.
dc.creatorNeves, H. H. R.
dc.creatorGomes, R. C.
dc.creatorGarcia, J. F.
dc.creatorFukumasu, H.
dc.creatorSilva, S. L.
dc.creatorLeme, P. R.
dc.creatorCoutinho, L. L.
dc.creatorEler, J. P.
dc.creatorFerraz, J. B. S.
dc.date2014-12-03T13:08:56Z
dc.date2016-10-25T20:09:35Z
dc.date2014-12-03T13:08:56Z
dc.date2016-10-25T20:09:35Z
dc.date2014-06-01
dc.date.accessioned2017-04-06T06:15:49Z
dc.date.available2017-04-06T06:15:49Z
dc.identifierJournal Of Animal Breeding And Genetics. Hoboken: Wiley-blackwell, v. 131, n. 3, p. 210-216, 2014.
dc.identifier0931-2668
dc.identifierhttp://hdl.handle.net/11449/111729
dc.identifierhttp://acervodigital.unesp.br/handle/11449/111729
dc.identifier10.1111/jbg.12084
dc.identifierWOS:000335958000007
dc.identifierhttp://dx.doi.org/10.1111/jbg.12084
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/922502
dc.descriptionThe genome-wide association study (GWAS) results are presented for average daily gain (ADG) in Nellore cattle. Phenotype of 720 male Bos indicus animals with information of ADG in feedlots and 354147 single-nucleotide polymorphisms (SNPs) obtained from a database added by information from Illumina Bovine HD (777962 SNPs) and Illumina BovineSNP50 (54609) by imputation were used. After quality control and imputation, 290620 SNPs remained in the association analysis, using R package Genome-wide Rapid Association using Mixed Model and Regression method GRAMMAR-Gamma. A genomic region with six significant SNPs, at Bonferroni-corrected significance, was found on chromosome 3. The most significant SNP (rs42518459, BTA3: 85849977, p=9.49x10(-8)) explained 5.62% of the phenotypic variance and had the allele substitution effect of -0.269kg/day. Important genes such as PDE4B, LEPR, CYP2J2 and FGGY are located near this region, which is overlapped by 12 quantitative trait locus (QTLs) described for several production traits. Other regions with markers with suggestive effects were identified in BTA6 and BTA10. This study showed regions with major effects on ADG in Bos indicus in feedlots. This information may be useful to increase the efficiency of selecting this trait and to understand the physiological processes involved in its regulation.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationJournal of Animal Breeding and Genetics
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBos indicus
dc.subjectgenomic
dc.subjectgrowth
dc.subjectgenome-wide association study
dc.subjectweight gain
dc.subjectzebu
dc.titleGenome-wide association study for feedlot average daily gain in Nellore cattle (Bos indicus)
dc.typeOtro


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