Morphological alterations of epidermis of rabbits infested by R. sanguineus ticks and exposed to Selamectin (active principle of Pfizer Revolution (R) acaricide): A confocal microscopy study

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBozzatto, Vlamir
dc.creatorOliveira, Patricia Rosa de
dc.creatorBechara, Gervasio Henrique
dc.creatorCamargo-Mathias, Maria Izabel
dc.date2014-12-03T13:08:41Z
dc.date2016-10-25T20:08:38Z
dc.date2014-12-03T13:08:41Z
dc.date2016-10-25T20:08:38Z
dc.date2014-01-01
dc.date.accessioned2017-04-06T06:13:22Z
dc.date.available2017-04-06T06:13:22Z
dc.identifierActa Histochemica. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 116, n. 3, p. 534-538, 2014.
dc.identifier0065-1281
dc.identifierhttp://hdl.handle.net/11449/111468
dc.identifierhttp://acervodigital.unesp.br/handle/11449/111468
dc.identifier10.1016/j.acthis.2013.11.011
dc.identifierWOS:000336780500015
dc.identifierhttp://dx.doi.org/10.1016/j.acthis.2013.11.011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/922247
dc.descriptionThe present study analyzed, by means of confocal laser scanning microscopy, the epidermis of rabbits infested by the brown dog tick Rhipicephalus sanguineus and exposed to concentrations of 50%, 80% and 100% of a selamectin-based commercial acaricide (Pfizer's Revolution (R)). The results demonstrated that rabbits exposed to concentrations of 80% and 100% of the Revolution acaricide, which contains 12% selamectin, showed thinning of epithelial tissue of the epidermis with associated cellular disorganization. Individuals exposed to a 50% concentration showed lower epidermal tissue disorganization when compared to those exposed to the higher doses of the acaricide (80% and 100%). Whereas selamectin, when used in higher concentrations (80% and 100% Revolution) can alter the morphology of the epidermis, at lower concentrations (50%), even though still able to eliminate ectoparasites, it causes less toxicity damage to the host. Selamectin can be considered a dose-dependent toxic agent, since higher concentrations increase the morphological changes in the epidermis of the host rabbits. (C) 2013 Elsevier GmbH. All rights reserved.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationActa Histochemica
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEpidermis
dc.subjectSelamectin
dc.subjectAcanthosis
dc.subjectPathology
dc.subjectToxicology
dc.subjectTicks
dc.subjectRabbit
dc.titleMorphological alterations of epidermis of rabbits infested by R. sanguineus ticks and exposed to Selamectin (active principle of Pfizer Revolution (R) acaricide): A confocal microscopy study
dc.typeOtro


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