Revisiting AFLP fingerprinting for an unbiased assessment of genetic structure and differentiation of taurine and zebu cattle

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorUtsunomiya, Yuri Tani
dc.creatorBomba, Lorenzo
dc.creatorLucente, Giordana
dc.creatorColli, Licia
dc.creatorNegrini, Riccardo
dc.creatorLenstra, Johannes Arjen
dc.creatorErhardt, Georg
dc.creatorGarcia, José Fernando
dc.creatorAjmone-Marsan, Paolo
dc.creatorEuropean Cattle Genetic Diversity
dc.date2014-12-03T13:07:04Z
dc.date2016-10-25T19:48:13Z
dc.date2014-12-03T13:07:04Z
dc.date2016-10-25T19:48:13Z
dc.date2014-04-17
dc.date.accessioned2017-04-06T06:02:44Z
dc.date.available2017-04-06T06:02:44Z
dc.identifierBmc Genetics. London: Biomed Central Ltd, v. 15, 10 p., 2014.
dc.identifier1471-2156
dc.identifierhttp://hdl.handle.net/11449/111219
dc.identifierhttp://acervodigital.unesp.br/handle/11449/111219
dc.identifier10.1186/1471-2156-15-47
dc.identifierWOS:000335177200001
dc.identifierWOS000335177200001.pdf
dc.identifierhttp://dx.doi.org/10.1186/1471-2156-15-47
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/922000
dc.descriptionBackground: Descendants from the extinct aurochs (Bos primigenius), taurine (Bos taurus) and zebu cattle (Bos indicus) were domesticated 10,000 years ago in Southwestern and Southern Asia, respectively, and colonized the world undergoing complex events of admixture and selection. Molecular data, in particular genome-wide single nucleotide polymorphism (SNP) markers, can complement historic and archaeological records to elucidate these past events. However, SNP ascertainment in cattle has been optimized for taurine breeds, imposing limitations to the study of diversity in zebu cattle. As amplified fragment length polymorphism (AFLP) markers are discovered and genotyped as the samples are assayed, this type of marker is free of ascertainment bias. In order to obtain unbiased assessments of genetic differentiation and structure in taurine and zebu cattle, we analyzed a dataset of 135 AFLP markers in 1,593 samples from 13 zebu and 58 taurine breeds, representing nine continental areas.Results: We found a geographical pattern of expected heterozygosity in European taurine breeds decreasing with the distance from the domestication centre, arguing against a large-scale introgression from European or African aurochs. Zebu cattle were found to be at least as diverse as taurine cattle. Western African zebu cattle were found to have diverged more from Indian zebu than South American zebu. Model-based clustering and ancestry informative markers analyses suggested that this is due to taurine introgression. Although a large part of South American zebu cattle also descend from taurine cows, we did not detect significant levels of taurine ancestry in these breeds, probably because of systematic backcrossing with zebu bulls. Furthermore, limited zebu introgression was found in Podolian taurine breeds in Italy.Conclusions: The assessment of cattle diversity reported here contributes an unbiased global view to genetic differentiation and structure of taurine and zebu cattle populations, which is essential for an effective conservation of the bovine genetic resources.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherBiomed Central Ltd.
dc.relationBMC Genetics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCattle
dc.subjectAFLP
dc.subjectGenetic differentiation
dc.subjectAscertainment bias
dc.titleRevisiting AFLP fingerprinting for an unbiased assessment of genetic structure and differentiation of taurine and zebu cattle
dc.typeOtro


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