Delineamentos experimentais eficientes para estudos de cinética química

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFerreira, Iuri E. P.
dc.creatorTrinca, Luzia A.
dc.creatorFerreira, Cláudia P.
dc.date2014-10-01T13:08:41Z
dc.date2016-10-25T19:45:24Z
dc.date2014-10-01T13:08:41Z
dc.date2016-10-25T19:45:24Z
dc.date2014
dc.date.accessioned2017-04-06T05:53:09Z
dc.date.available2017-04-06T05:53:09Z
dc.identifierQuímica Nova. Sociedade Brasileira de Química, v. 37, n. 4, p. 589-596, 2014.
dc.identifier0100-4042
dc.identifierhttp://hdl.handle.net/11449/109929
dc.identifierhttp://acervodigital.unesp.br/handle/11449/109929
dc.identifier10.5935/0100-4042.20140102
dc.identifierS0100-40422014000400003
dc.identifierS0100-40422014000400003.pdf
dc.identifierhttp://dx.doi.org/10.5935/0100-4042.20140102
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/920738
dc.descriptionIn this paper we show how to obtain efficient designs of experiments for fitting Michaelis-Menten and Hill equations useful in chemical studies. The search of exact D-optimal designs by using local and pseudo-Bayesian approaches is considered. Optimal designs were compared to those commonly used in practice using an efficiency measure and theoretical standard errors of the kinetic parameter estimates. In conclusion, the D-optimal designs based on the Hill equation proved efficient for estimating the parameters of both models. Furthermore, these are promising with respect to practical issues, allowing efficient estimation as well as goodness-of-fit tests and comparisons between some kinetic models.
dc.languagepor
dc.publisherSociedade Brasileira de Química
dc.relationQuímica Nova
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectoptimum design theory
dc.subjectMichaelis-Menten kinetics
dc.subjectHill equation
dc.titleDelineamentos experimentais eficientes para estudos de cinética química
dc.typeOtro


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