Prozone effects in microscopic agglutination tests for leptospirosis in the sera of mice infected with the pathogenic Leptospira interrogans serovar Canicola

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorShimabukuro, Fabio Hiroto
dc.creatorCosta, Veruska Maia Da
dc.creatorSilva, Rodrigo Costa da
dc.creatorLangoni, Hélio
dc.creatorSilva, Aristeu Vieira da
dc.creatorCarvalho, Lidia Raquel de
dc.creatorDomingues, Paulo Francisco
dc.date2014-10-01T13:08:38Z
dc.date2016-10-25T19:45:17Z
dc.date2014-10-01T13:08:38Z
dc.date2016-10-25T19:45:17Z
dc.date2013-08-01
dc.date.accessioned2017-04-06T05:52:46Z
dc.date.available2017-04-06T05:52:46Z
dc.identifierMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 108, n. 5, p. 668-670, 2013.
dc.identifier0074-0276
dc.identifierhttp://hdl.handle.net/11449/109882
dc.identifierhttp://acervodigital.unesp.br/handle/11449/109882
dc.identifier10.1590/0074-0276108052013022
dc.identifierS0074-02762013000500668
dc.identifierS0074-0276108052013022
dc.identifierWOS:000322520800022
dc.identifierS0074-02762013000500668.pdf
dc.identifier2-s2.0-84879578089
dc.identifierhttp://dx.doi.org/10.1590/0074-0276108052013022
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/920691
dc.descriptionMice experimentally infected with a pathogenic strain of Leptospira interrogans serovar Canicola produced false negative results (prozone effect) in a microscopic agglutination test (MAT). This prozone effect occurred in several serum samples collected at different post-infection times, but it was more prominent in samples collected from seven-42 days post-infection and for 1:50 and 1:100 sample dilutions. This phenomenon was correlated with increased antibody titres in the early post-infection phase. While prozone effects are often observed in serological agglutination assays for the diagnosis of animal brucellosis and human syphilis, they are not widely reported in leptospirosis MATs.
dc.languageeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relationMemórias do Instituto Oswaldo Cruz
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmicroscopic agglutination test
dc.subjectprozone effect
dc.subjectleptospirosis
dc.titleProzone effects in microscopic agglutination tests for leptospirosis in the sera of mice infected with the pathogenic Leptospira interrogans serovar Canicola
dc.typeOtro


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