Cryotherapy as an adjuvant in the treatment with vismodegib for local advanced nonsurgical basal cell carcinoma: a report of 8 cases

dc.creatorCastillo Molina, David
dc.creatorFierro Lozada, Jesus Daniel
dc.creatorGarcía C., Ana María
dc.creatorMolano Pérez, Manuela Alejandra
dc.creatorCantillo Avilez, Melissa
dc.creatorGuerrero Roncancio, Laura
dc.creatorMuñoz-Ordoñez, Sara
dc.creatorCampo Slebi, Isabella
dc.creatorALVIS-ZAKZUK, NELSON J.
dc.creatorCastillo Saavedra, David E.
dc.creatorMartinez Zuñiga, Diego M.
dc.date2022-06-24T13:44:49Z
dc.date2022-06-24T13:44:49Z
dc.date2021-09-01
dc.date.accessioned2023-10-03T20:09:54Z
dc.date.available2023-10-03T20:09:54Z
dc.identifierDavid A. Castillo Molina, Jesus D. Fierro Lozada, Ana María García C, Manuela A. Molano Pérez, Melissa Cantillo Avilez, Laura Guerrero-Roncancio, Sara Muñoz-Ordoñez, Isabella Campo Slebi, Nelson José Alvis-Zakzuk, David E. Castillo Saavedra, Diego M. Martinez Zuñiga, 27143 Cryotherapy as an adjuvant in the treatment with vismodegib for local advanced nonsurgical basal cell carcinoma: A report of 8 cases, Journal of the American Academy of Dermatology, Volume 85, Issue 3, Supplement, 2021, Page AB131, ISSN 0190-9622, https://doi.org/10.1016/j.jaad.2021.06.541.
dc.identifier0190-9622
dc.identifierhttps://hdl.handle.net/11323/9307
dc.identifierhttps://doi.org/10.1016/j.jaad.2021.06.541
dc.identifier10.1016/j.jaad.2021.06.541
dc.identifier1097-6787
dc.identifierCorporación Universidad de la Costa
dc.identifierREDICUC - Repositorio CUC
dc.identifierhttps://repositorio.cuc.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9174665
dc.descriptionIntroduction: Basal cell carcinoma (BCC) is the most prevalent skin cancer worldwide. The most frequently used treatment for BCC is surgical resection. Lately, there are other options for nonsurgical BCC such as hedgehog pathways inhibitors, which is indicated in patients whose cancer is locally advanced and unresectable. We described the response of patients treated with vismodegib and cryotherapy as adjuvant management. Materials and methods: We conducted an observational retrospective study in a dermatologic center in Bogota, Colombia. We included patients with BCC diagnosis and were treated with vismodegib and cryotherapy from January 2018 to August 2020. Variables included age, sex, phototype, lesion location, treatment duration, number of cryotherapies, months of follow-up, and histologic subtypes. Variables were analyzed using Microsoft Excel 2016. Results: Of eight patients reviewed, four were female. Median age was 70 years old. Photoype III was the most frequent. Zone H was the most affected location. The mean number of cryotherapy sessions received during vismodegib treatment was 4.75, and the mean duration of treatment with the hedgehog inhibitor was 3.5 months. Patients were followed up for 15.57 months. Of the eight patients, four presented nodular pattern histology, in the rest the mixed subtype predominated. Conclusion: In general, there was a good response to treatment with a notable decrease in the size and control of the lesions. No side effects were described during the follow-up time; however, the patients will continue to be under strict controls.
dc.format1 página
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherMosby Inc.
dc.publisherUnited States
dc.relationJournal of the American Academy of Dermatology
dc.relation3
dc.relation85
dc.rights© 2021 Published by Elsevier Inc.
dc.rightsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.sourcehttps://www.sciencedirect.com/science/article/pii/S0190962221016455?via%3Dihub
dc.subjectCryotherapy
dc.subjectVismodegib
dc.subjectBasal cell carcinoma
dc.titleCryotherapy as an adjuvant in the treatment with vismodegib for local advanced nonsurgical basal cell carcinoma: a report of 8 cases
dc.typeArtículo de revista
dc.typehttp://purl.org/coar/resource_type/c_6501
dc.typeText
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/redcol/resource_type/ART
dc.typeinfo:eu-repo/semantics/acceptedVersion
dc.typehttp://purl.org/coar/version/c_ab4af688f83e57aa


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