Acerca de la inestabilidad de las memorias y su transformación por el proceso de reconsolidación: aportes para su consideración clínica

On the instability of memories and its transformation by the reconsolidation process: Contributions for its clinical consideration

dc.creatorFernández, Rodrigo S
dc.creatorAllegri, Ricardo
dc.date2020-11-24T16:24:48Z
dc.date2020-11-24T16:24:48Z
dc.date2019
dc.date.accessioned2023-10-03T20:01:05Z
dc.date.available2023-10-03T20:01:05Z
dc.identifierhttps://hdl.handle.net/11323/7454
dc.identifierhttps://doi.org/10.1016/j.neuarg.2019.06.002
dc.identifierCorporación Universidad de la Costa
dc.identifierREDICUC - Repositorio CUC
dc.identifierhttps://repositorio.cuc.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9173881
dc.descriptionIntroducción En condiciones normales, nuestro cerebro es capaz de actualizar sus representaciones almacenadas en fuerza o contenido por el proceso de reconsolidación. De esta forma, una memoria consolidada es reactivada y entra en un periodo transitorio de inestabilidad seguido por una fase de reestabilización para persistir. El inicio del proceso de reconsolidación depende de la detección de una incongruencia entre la predicción realizada y lo ocurrido (error de predicción), en el que la predicción inicial se ajusta acorde al error generado. Desarrollo La neurociencia, la psicología y otras ciencias básicas han aportado perspectivas novedosas en la investigación y abordaje de diversos trastornos psiquiátricos. En este sentido, establecieron una relación íntima entre la memoria y las enfermedades mentales. El paradigma de la reconsolidación de la memoria ha sido propuesto no solo como el mecanismo responsable del mantenimiento de algunas psicopatologías sino también como una oportunidad de establecer nuevos tratamientos. En la presente revisión se desarrollará el concepto de reconsolidación, ampliamente estudiado en animales y humanos en los últimos 20 años, y se destacarán sus potenciales aplicaciones traslacionales a la clínica neuropsiquiátrica. Conclusiones Existen evidencias de que el proceso de reconsolidación tendría utilidad terapéutica en la clínica neuropsiquiátrica. Sin embargo, aún se requieren estudios mayores y más complejos.
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dc.formatapplication/pdf
dc.languagespa
dc.publisherCorporación Universidad de la Costa
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dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
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dc.sourceNeurología Argentina
dc.sourcehttps://www.sciencedirect.com/science/article/abs/pii/S1853002819300473?via%3Dihub
dc.subjectMemoria
dc.subjectReconsolidación
dc.subjectConsolidación
dc.subjectError de predicción
dc.subjectTraslacional
dc.subjectNeuropsiquiatría
dc.titleAcerca de la inestabilidad de las memorias y su transformación por el proceso de reconsolidación: aportes para su consideración clínica
dc.titleOn the instability of memories and its transformation by the reconsolidation process: Contributions for its clinical consideration
dc.typeArtículo de revista
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