Effectiveness of deep brain stimulation in refractory and drug-resistant aggressiveness in autism spectrum disorder

dc.creatorBenedetti-Isaac, Juan Carlos
dc.creatorCamargo, Loida
dc.creatorCardenas, Fernando P.
dc.creatorLopez, Norman
dc.date2023-08-23T21:25:50Z
dc.date2025
dc.date2023-08-23T21:25:50Z
dc.date2023
dc.date.accessioned2023-10-03T19:43:13Z
dc.date.available2023-10-03T19:43:13Z
dc.identifierJuanCarlos Benedetti-Isaac, Loida Camargo, Fernando P. Cardenas, Norman López, Effectiveness of deep brain stimulation in refractory and drug-resistant aggressiveness in autism spectrum disorder, Research in Autism Spectrum Disorders, Volume 102, 2023, 102131, ISSN 1750-9467, https://doi.org/10.1016/j.rasd.2023.102131
dc.identifier1750-9467
dc.identifierhttps://hdl.handle.net/11323/10402
dc.identifier10.1016/j.rasd.2023.102131
dc.identifierCorporación Universidad de la Costa
dc.identifierREDICUC - Repositorio CUC
dc.identifierhttps://repositorio.cuc.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9171742
dc.descriptionBackground. Aggressive behavior, resistant to pharmacological and psychological treatment, is observed in some cases of autism. The main objective of this study is to analyze the efficacy of deep brain stimulation (DBS) for aggressive behavior in severe autism. Method. The effectiveness of DBS was analyzed in a clinical follow-up of 5 autistic patients, with impaired functional activity and refractoriness to psychopharmacological and behavioral treatment. The patients were examined in medical meetings and evaluated by experienced professionals using the Overt Aggressiveness Scale (OAS), before surgical implantation and after 6, 12 and, 18 months of follow-up. Student's t-test analyses were performed to assess changes in aggressiveness scores. The effect size of surgical intervention on patients' OAS performance was estimated. Results. Before the intervention, patients scored very high on the aggressiveness scale. In the subsequent medical controls, a clinically and psychometrically significant decrease in aggressiveness and self-injury symptoms was observed. These data were confirmed by the parents up to 18 months of follow-up. Very large effect sizes were obtained in favor of DBS. Conclusions. In this case series, DBS significantly reduced aggressiveness and self-injury, favoring functionality, social adaptation of the patients, and improving the quality of life of the family. We believe that DBS may be a viable treatment option.
dc.format10 páginas
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier BV
dc.publisherNetherlands
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dc.relation1
dc.relation102
dc.rights© 2023 The Authors. Published by Elsevier Ltd.
dc.rightsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.rightshttp://purl.org/coar/access_right/c_f1cf
dc.sourcehttps://www.sciencedirect.com/science/article/pii/S1750946723000314#:~:text=We%20conclude%20that%20DBS%20is,and%20that%20of%20their%20caregivers.
dc.subjectDBS
dc.subjectSevere
dc.subjectASD
dc.subjectRefractory aggressiveness
dc.titleEffectiveness of deep brain stimulation in refractory and drug-resistant aggressiveness in autism spectrum disorder
dc.typeArtículo de revista
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typeText
dc.typeinfo:eu-repo/semantics/article
dc.typehttp://purl.org/redcol/resource_type/ART
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/version/c_970fb48d4fbd8a85


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