Moving from neurodegenerative dementias, to cognitive proteinopathies, replacing “where” by “what”

dc.creatorAllegri, Ricardo Francisco
dc.date2021-03-12T15:55:18Z
dc.date2021-03-12T15:55:18Z
dc.date2020-09-18
dc.date.accessioned2023-10-03T19:22:44Z
dc.date.available2023-10-03T19:22:44Z
dc.identifier19805764
dc.identifierhttps://hdl.handle.net/11323/7992
dc.identifierhttps://doi.org/10.1590/1980-57642020dn14-030005
dc.identifierCorporación Universidad de la Costa
dc.identifierREDICUC - Repositorio CUC
dc.identifierhttps://repositorio.cuc.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9169813
dc.descriptionNeurodegenerative dementias have been described based on their phenotype, in relation to selective degeneration occurring in a particular neuroanatomical system. More recently however, the term proteinopathy has been introduced to describe diseases in which one or more altered proteins can be detected. Neurodegenerative diseases can be produced by more than one abnormal protein and each proteinopathy can determine different clinical phenotypes. Specific biomarkers have now been linked to certain molecular pathologies in live patients. In 2016, a new biomarker-based classification, currently only approved for research in Alzheimer’s disease, was introduced. It is based on the evaluation three biomarkers: amyloid (A) detected on amyloid-PET or amyloid- beta 42 assay in CSF; tau (T) measured in CSF as phosphorylated tau or on tau PET imaging; and neuronal injury/neurodegeneration (N), detected by total T-tau in CSF, FDG PET hypometabolism and on MRI brain scan. Results of clinical research using the ATN biomarkers at FLENI, a Neurological Institute in Buenos Aires, Argentina have, since 2011, contributed to ongoing efforts to move away from the concept of neurodegenerative dementias and more towards one of cognitive proteinopathies. Today, clinical diagnosis in dementia can only tell us “where” abnormal tissue is found but not “what” molecular mechanisms are involved
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dc.formatapplication/pdf
dc.languageeng
dc.publisherCorporación Universidad de la Costa
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dc.rightsCC0 1.0 Universal
dc.rightshttp://creativecommons.org/publicdomain/zero/1.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.sourceDementia e Neuropsychologia
dc.sourcehttps://www.scielo.br/scielo.php?pid=S1980-57642020000300237&script=sci_arttext
dc.subjectAlzheimer disease
dc.subjectProteins
dc.subjectFrontotemporal dementia
dc.subjectBiomarkers
dc.subjectDementia
dc.titleMoving from neurodegenerative dementias, to cognitive proteinopathies, replacing “where” by “what”
dc.typeArtículo de revista
dc.typehttp://purl.org/coar/resource_type/c_6501
dc.typeText
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/redcol/resource_type/ART
dc.typeinfo:eu-repo/semantics/acceptedVersion
dc.typehttp://purl.org/coar/version/c_ab4af688f83e57aa


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