Social cognition in early multiple sclerosis: neuropsychological and anatomical approach

La cognición social en la esclerosis múltiple temprana: enfoque neuropsicológico y anatómico

dc.creatorCrivelli, Lucía
dc.creatorCalandri, Ismael Luis
dc.creatorHelou, Belén
dc.creatorKeller, Greta
dc.creatorFiol, Marcela Paula
dc.creatorYsraelit, María-Célica
dc.creatorGaitán, María-Inés
dc.creatorCorreale, Jorge
dc.date2023-05-15T13:09:09Z
dc.date2023-05-15T13:09:09Z
dc.date2021-03-27
dc.date.accessioned2023-10-03T19:12:14Z
dc.date.available2023-10-03T19:12:14Z
dc.identifierCrivelli, L., Calandri, I.-L., Helou, B., Keller, G., Fiol, M.-P., Ysraelit, M.-C., Gaitan, M.-I., & Correale, J. (2021). Social Cognition In Early Multiple Sclerosis: Neuropsychological And Anatomical Approach: Cognición Social En La Esclerosis Múltiple Temprana: Enfoque Neuropsicológico Y Anatómico. Journal of Applied Cognitive Neuroscience, 2(1), e00153735. https://doi.org/10.17981/JACN.2.1.2021.03
dc.identifierhttps://hdl.handle.net/11323/10133
dc.identifier10.17981/JACN.2.1.2021.03
dc.identifier2745-0031
dc.identifierCorporación Universidad de la Costa
dc.identifierREDICUC – Repositorio CUC
dc.identifierhttps://repositorio.cuc.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9168850
dc.descriptionCognitive impairment and deficits in Social Cognition (SC) are frequent in patients with Multiple Sclerosis (MS). The aim of the present work is to study SC in patients with early MS and to analyze its neuroanatomical correlation. Thirty-four patients with relapsing remitting MS, with ≤ 2 years of disease progression and EDSS and ≤ 2, and 30 healthy control subjects matched for age, sex, and educational level were recruited. Subjects performed a comprehensive neuropsychological assessment (Rao BRB). SC was assessed using the International Affective Picture System IAPS, The Eyes in the Mind Test, the Empathy Quotient, and the Faux Pas Test. The anatomical correlation of patients with deficits in social cognition was studied through brain MRI and voxel-based morphometric for which cortical reconstruction and volumetric segmentation were performed using Freesurfer processing software. Patients showed significant deficits in executive functions, verbal memory and language tests. SC assessment showed that patients presented greater difficulties in the Faux Pas Test (p = 0.023), The Mind in the Eyes Test (p = 0.014), and presented a positive bias in the interpretation of neutral images of the IAPS (P = 0.023). Furthermore, patients with CS deficits presented less cortical thickness in areas of the right supramarginal gyrus, pars opercularis, and anterior cingulum.
dc.descriptionEl deterioro cognitivo y los déficits en la cognición Social (CS) son frecuentes en pacientes con Esclerosis Múltiple (EM). El objetivo del presente trabajo es estudiar la CS en pacientes con EM temprana y analizar su correlación neuroanatómica. Se reclutaron 34 pacientes con EM remitente recidivante, con ≤ 2 años de progresión de la enfermedad y EDSS y ≤ 2, y 30 sujetos control sanos emparejados por edad, sexo y nivel educativo. Los sujetos realizaron una evaluación neuropsicológica completa (Rao BRB). La CS se evaluó mediante el Sistema Internacional de Imágenes Afectivas IAPS, el Test de la Mirada, el Cociente de Empatía y el Test de Faux Pas. La correlación anatómica de los pacientes con los déficits en cognición social se estudió mediante resonancia magnética cerebral y morfometría basada en vóxeles, para lo cual se realizó la reconstrucción cortical y la segmentación volumétrica mediante el software de procesamiento Freesurfer. Los pacientes mostraron déficits significativos en las funciones ejecutivas, la memoria verbal y las pruebas de lenguaje. La evaluación de la CS mostró que los pacientes presentaban mayores dificultades en el Faux Pas Test (p = 0.023), el Test de la Mirada (p = 0.014), y presentaban un sesgo positivo en la interpretación de imágenes neutras del IAPS (P = 0.023). Además, los pacientes con déficits de CS presentaron un menor grosor cortical en áreas del giro supramarginal derecho, la pars opercularis y el cíngulo anterior.
dc.format14 páginas
dc.formatapplication/pdf
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dc.languageeng
dc.publisherCorporación Universidad de la Costa
dc.publisherColombia
dc.relationJournal of Applied Cognitive Neuroscience
dc.relationApps, M. A.; Rushworth, M. F. & Chang, S. W. (2016). The Anterior Cingulate Gyrus and Social Cognition: Tracking the Motivation of Others. Neuron, 90(4), 692–707. https://doi.org/10.1016/j.neuron.2016.04.018
dc.relationBanati, M.; Sandor, J.; Mike A.; Illes, E.; Bors, L.; Feldmann, A.; Herold, R. & Illes, Z. (2010). Social cognition and Theory of Mind in patients with relapsing-remitting multiple sclerosis. Europena Journal of Neurology, 17(3), 426–433. https://doi.org/10.1111/j.1468-1331.2009.02836.x
dc.relationBaron-Cohen, S. & Wheelwright, S. (2004). The Empathy Quotient: An Investigation Of Adults With Asperger Syndrome Or High Functioning Autism, And NormalSex Differences, Journal of Autism and Developmental Disorders, 34(2), 163–175. https://doi.org/10.1023/b:jadd.0000022607.19833.00
dc.relationBatista, S.; D’Almeida, O. C.; Afonso, A.; Freitas, S.; Macário, C.; Sousa, L.; Castelo-Branco, M.; Santana, I. & Cunha, L. (2017). Impairment of social cognition in multiple sclerosis: Amygdala atrophy is the main predictor. Multiple Sclerosis Journal, 23(10), 1358–1366. https://doi.org/10.1177/1352458516680750
dc.relationBradley, M. & Lang, P. (1994). Measuring emotion: The self-assessment manikin and the semantic differential. Journal of Behavior Therapy and Experimental Psychiatry, 25(1), 49–59. https://doi.org/10.1016/0005-7916(94)90063-9
dc.relationCáceres, F.; Vanotti, S.; Rao, S. & RECONEM Workgroup. (2011). Epidemiological characteristics of cognitive impairment of multiple sclerosis patients in a Latin American country. Journal of Clinical and Experimental Neuropsychology, 33(10), 1094–1098. https://doi.org/10.1080/13803395.2011.603690
dc.relationCalder, A. J.; Keane, J.; Lawrence, A. D. & Manes F. (2004). Impaired recognition of anger following damage to the ventral striatum. Brain: a journal of Neulogy, 127(Pt 9), 1958–1969. https://doi.org/10.1093/brain/awh214
dc.relationChiaravalloti, N. D. & DeLuca, J. (2008). Cognitive impairment in multiple sclerosis. The Lancet Neurol, 7(12), 1139–1151. https://doi.org/10.1016/s1474-4422(08)70259-x
dc.relationCotter J.; Firth, J.; Enzinger, C.; Kontopantelis, E.; Yung, A. R.; Elliott, R. & Drake, R. J. (2016). Social cognition in multiple sclerosis: A systematic review and meta-analysis. Neurology, 87(16), 1727–1736. https://doi.org/10.1212/wnl.0000000000003236
dc.relationDi Bitonto, L.; Longato, N.; Jung, B.; Fleury, M.; Marcel, C.; Collongues, N.; de Seze, J. & Blanc, F. (2011). Reduced emotional reactivity to negative stimuli in multiple sclerosis, preliminary results. Revue Neurolique (Paris), 167(11), 820–826. https://doi.org/10.1016/j.neurol.2011.01.02477
dc.relationHenry, J. D.; Phillips, L. H.; Beatty, W. W.; McDonald, S.; Longley, W. A.; Joscelyne, A. & Rendell, P. G. (2009). Evidence for deficits in facial affect recognition and theory of mind in multiple sclerosis. Journal of the International Neuropsychological Society, 15(2), 277–285. https://doi.org/10.1017/s1355617709090195
dc.relationJehna, M.; Langkammer, C.; Wallner-Blazek, M.; Neuper, Ch.; Loitfelder, M.; Ropele, S.; Fuchs, S.; Khalil, M.; Pluta-Fuerst, A.; Fazekas, F. & Enzinger, Ch. (2011). Cognitively preserved MS patients demonstrate functional differences in processing neutral and emotional faces. Brain Imaging and Behavior, 5(4), 241–251. https://doi.org/10.1007/s11682-011-9128-1
dc.relationKurtzke J. F. (1983). Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology, 33(11), 1444–1452. https://doi.org/10.1212/wnl.33.11.1444
dc.relationLang, P. J.; Bradley, M. M. & Cuthbert, B. N. (2008). International affective picture system (IAPS): Affective ratings of pictures and instruction manual. [Technical Report A-8]. Gainesville: University of Florida. Available from https://www2.unifesp.br/dpsicobio/adap/instructions.pdf
dc.relationLangdon, D. W. (2011). Cognition in Multiple Sclerosis. Current Opinion in Neurology, 24(3), 244–249. https://doi.org/10.1097/wco.0b013e328346a43b
dc.relationLouwerse, A.; Tulen, J. H.; van der Geest, J. N.; van der Ende, J. & Verhulst, F. C. (2014). Greaves-Lord K. Autonomic responses to social and nonsocial pictures in adolescents with autism spectrum disorder. Autism Research, 7(1), 17–27. https://doi.org/10.1002/aur.1327
dc.relationMao, C. V.; Araujo, M. F.; Nishimaru, H.; Matsumoto, J.; Tran, A. H.; Hori, E.; Ono, T. & Nishijo, H. (2017). Pregenual Anterior Cingulate Gyrus Involvement in Spontaneous Social Interactions in Primates-Evidence from Behavioral, Pharmacological, Neuropsychiatric, and Neurophysiological Findings. Frontiers in Neuroscience, 11, 1–10. https://dx.doi.org/10.3389%2Ffnins.2017.00034
dc.relationMcDonald, W. I.; Compston, A.; Edan, G.; Goodkin, D.; Hartung, H. P.; Lublin, F. D.; McFarland, H. F.; Paty, D. W.; Polman, C. H.; Reingold, S. C.; Sandberg-Wollheim, M.; Sibley, W.; Thompson, A.; Van den Noort, S.; Weinshenker, B. Y.; Wolinsky, J. S. (2001). Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Annals of Neurology, 50(1), 121–127. https://doi.org/10.1002/ana.1032
dc.relationOuellet, J.; Scherzer, P. B.; Rouleau, I.; Métras, P.; Bertrand-Gauvin, C.; Djerroud, N.; Boisseau E. & Duquette, P. (2010). Assessment of social cognition in patients with multiple sclerosis. Journal of the IntNeuropsychological Society, 16(2), 287–296. https://doi.org/10.1017/s1355617709991329
dc.relationRomán, F.; Rojas, Galeno; N. R., Iturry, M.; Blanco, R.; Leis, A.; Bartoloni, L. & Allegri , R. F. (2012). Baremos del Test de la Mirada en español en adultos normales de Buenos Aires. Revista Neuropsicología Latinoamericana, 4(3), 1–5. Disponible en https://www.neuropsicolatina.org/index.php/Neuropsicologia_Latinoamericana/article/view/108
dc.relationSchulz, K. P.; Clerkin, S. M.; Halperin, J. M.; Newcorn, J. H.; Tang, C. Y. & Fan, J. (2009). Dissociable neural effects of stimulus valence and preceding context during the inhibition of responses to emotional faces. Hum Brain Mapp, 30(9), 2821–2833. https://doi.org/10.1002/hbm.20706
dc.relationSprengelmeyer, R.; Young, A. W., Calder, A. J., Karnat, A.; Lange, H.; Hömberg, V.; Perrett, D. I. & Rowland, D. (1996). Loss of disgust. Perception of faces and emotions in Huntington’s disease. Brain: a journal of Neulogy, 119( Pt 5), 1647–1665. https://doi.org/10.1093/brain/119.5.1647
dc.relationStone, V. E.; Baron-Cohen, S. & Knight, R. T. (1998). Frontal lobe contributions to theory of mind. Journal of Cognitive Neuroscience, 10(5), 640–656. https://doi.org/10.1162/089892998562942
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dc.rightsCopyright (c) 2021 Journal of Applied Cognitive Neuroscience
dc.rightsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.sourcehttps://revistascientificas.cuc.edu.co/JACN/article/view/3735
dc.subjectCognitive dysfunction
dc.subjectSocial cognition
dc.subjectMultiple sclerosis
dc.subjectNeuropsychological test
dc.subjectDisease progression
dc.subjectDisfunción cognitiva
dc.subjectCognición social
dc.subjectEsclerosis múltiple
dc.subjectTest neuropsicológico
dc.subjectProgresión de la enfermedad
dc.titleSocial cognition in early multiple sclerosis: neuropsychological and anatomical approach
dc.titleLa cognición social en la esclerosis múltiple temprana: enfoque neuropsicológico y anatómico
dc.typeArtículo de revista
dc.typehttp://purl.org/coar/resource_type/c_6501
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typeText
dc.typeinfo:eu-repo/semantics/article
dc.typehttp://purl.org/redcol/resource_type/ART
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/version/c_970fb48d4fbd8a85


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