Optic tract and internal capsule lesion in a patient with Wernicke-Korsakoff syndrome
Lesión del tracto óptico y de la cápsula interna en un paciente con síndrome de Wernicke-Korsakoff
| dc.creator | Hernández, Micaela-Anahí | |
| dc.creator | Varela, Francisco | |
| dc.creator | Bensi, Catalina | |
| dc.date | 2023-05-12T21:55:17Z | |
| dc.date | 2023-05-12T21:55:17Z | |
| dc.date | 2020-12-07 | |
| dc.date.accessioned | 2023-10-03T19:05:44Z | |
| dc.date.available | 2023-10-03T19:05:44Z | |
| dc.identifier | Hernández, M.-A., Varela, F., & Bensi, C. (2020). Optic tract and internal capsule lesion in a patient with Wernicke-Korsakoff syndrome: Lesión del tracto óptico y de la cápsula interna en un paciente con síndrome de Wernicke-Korsakoff. Journal of Applied Cognitive Neuroscience, 1(1), 101–103. https://doi.org/10.17981/JACN.1.1.2020.07 | |
| dc.identifier | https://hdl.handle.net/11323/10125 | |
| dc.identifier | 10.17981/JACN.1.1.2020.07 | |
| dc.identifier | 2745-0031 | |
| dc.identifier | Corporación Universidad de la Costa | |
| dc.identifier | REDICUC - Repositorio CUC | |
| dc.identifier | https://repositorio.cuc.edu.co/ | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9167623 | |
| dc.description | A 72-year-old man, presented with a one-week history of confusion and an anterograde amnesic disorder accompanied by confabulation, with lack of insight to his symptoms. Medical history included alcohol abuse and admitted twenty-years of alcohol ingestion (approximately 186 gr/day). Neurologic examination was notable for slightly decreased consciousness, disorientation to time, severe anterograde amnesia and unsteadiness of stance and gait with four limb ataxia. A metabolic blood panel including liver profile showed alanine aminotransferase mildly elevated (66 UI/L) with elevated gamma-glutamyl-transpeptidase (gGT: 426 UI/L). Tests for HIV, syphilis and vitamin B12 levels were negative. Review of initial brain MRI showed a symmetrical, increased fluid-attenuated inversion recovery (FLAIR) signal lesion extending through the hypothalamus, periaqueductal area, mamillary bodies, bilateral anterior thalami, chiasm, both optic tracts and posterior limbs of both internal capsules with restricted diffusion and patchy contrast enhancement (figure 1 1a-1b). A possible Wernicke-Korsakoff syndrome diagnosis was achived. Following the initial examination, the patient was initiated on prophylactic parenteral thiamine reposition. CSF analysis showed elevated proteins (174 mg/dl) and lactate concentration (2.9 mmol/L). Cytologic and immunocytochemical study showed no neoplastic processes. Screening of autoimmune antibodies in CSF and paraneoplastic antibodies in serum were negative. EEG and full-body CT scans were unremarkable. Thiamine serum levels were normal (16,5 ug/L) (blood sample collected previous to reposition). Finally, a neurocognitive test indicated malperformance in tasks related to immediate and delayed recall and disturbances in recent and remote memory with confabulation. A new brain MRI after supplementation showed regression of the previous lesion (figure 1 2a-2b). He was discharged one month later with residual anterograde amnesia and gait instability that are still present eleven months later, at the last follow up. | |
| dc.format | 3 páginas | |
| dc.format | application/pdf | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Corporación Universidad de la Costa | |
| dc.publisher | Colombia | |
| dc.relation | Journal of Applied Cognitive Neuroscience | |
| dc.relation | Isenberg-Grzeda, E., Rahane, S., DeRosa, A., Ellis, J. & Nicolson, S. (2016). Wernicke-Korsakoff syndrome in patients with cancer: a systematic review. The Lancet Oncology, 17(4), e142–e148. https://doi.org/10.1016/S1470-2045(16)00037-1 | |
| dc.relation | Sinha, S., Kataria, A., Kolla, B., Thusius, N. & Loukianova, L. (2019). Wernicke Encephalopathy-Clinical Pearls. Mayo Clinic Proceedings, 94(6), 1065–1072. https://doi.org/10.1016/j.mayocp.2019.02.018 | |
| dc.relation | Sullivan, E. & Pfefferbaum, A. (2009). Neuroimaging of the Wernicke-Korsakoff syndrome. Alcohol and Alcoholism, 44(2), 155–165. https://doi.org/10.1093/alcalc/agn103 | |
| dc.relation | Wicklund, M. & Knopman, D. (2013). Brain MRI findings in Wernicke encephalopathy. Neurology Clinical Practice, 3(4), 363–364. https://doi.org/10.1212/ CPJ.0b013e3182a1ba00 | |
| dc.relation | 103 | |
| dc.relation | 101 | |
| dc.relation | 1 | |
| dc.relation | 1 | |
| dc.rights | Copyright (c) 2020 Journal of Applied Cognitive Neuroscience | |
| dc.rights | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) | |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.source | https://revistascientificas.cuc.edu.co/JACN/article/view/3341 | |
| dc.subject | Wernicke’s encephalopathy | |
| dc.subject | Wernicke-Korsakoff Syndrome | |
| dc.subject | vitamin B1 deficiency | |
| dc.title | Optic tract and internal capsule lesion in a patient with Wernicke-Korsakoff syndrome | |
| dc.title | Lesión del tracto óptico y de la cápsula interna en un paciente con síndrome de Wernicke-Korsakoff | |
| dc.type | Artículo de revista | |
| dc.type | http://purl.org/coar/resource_type/c_6501 | |
| dc.type | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.type | Text | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | http://purl.org/redcol/resource_type/ART | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | http://purl.org/coar/version/c_970fb48d4fbd8a85 |