Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation

dc.creatorCacemiro, Maira da Costa
dc.creatorCominal, Juçara Gastaldi
dc.creatorTognon, Raquel
dc.creatorNunes, Natalia de Souza
dc.creatorSimões, Belinda Pinto
dc.creatorFigueiredo-Pontes, Lorena Lôbo de
dc.creatorCatto, Luiz Fernando Bazzo
dc.creatorTraina, Fabíola
dc.creatorSouto, Elizabeth Xisto
dc.creatorZambuzi, Fabiana Albani
dc.creatorFrantz, Fabiani Gai
dc.creatorCastro, Fabíola Attié de
dc.date2019-02-25T17:56:23Z
dc.date2019-02-22
dc.date2019-02-25T17:56:23Z
dc.date2018-06
dc.date.accessioned2023-09-29T15:34:31Z
dc.date.available2023-09-29T15:34:31Z
dc.identifierhttp://dx.doi.org/10.1016/j.htct.2017.12.003
dc.identifierhttps://repositorio.ufjf.br/jspui/handle/ufjf/9213
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9129990
dc.descriptionBackground: Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms. Methods: This study examined the plasma cytokine profiles of patients with essential thrombocythemia, primary myelofibrosis, polycythemia vera and of healthy subjects, and analyzed correlations with JAK2 V617F status and clinical-hematological parameters. Results: The proinflammatory cytokine levels were increased in myeloproliferative neoplasm patients, and the presence of the JAK2 V617F mutation was associated with high IP-10 levels in primary myelofibrosis patients. Conclusions: Essential thrombocythemia, primary myelofibrosis, and polycythemia vera patients exhibited different patterns of cytokine production, as revealed by cytokine network correlations. Together, these findings suggest that augmented cytokine levels are associated with the physiopathology of myeloproliferative neoplasms.
dc.description-
dc.formatapplication/pdf
dc.languageeng
dc.publisher-
dc.publisherBrasil
dc.publisher-
dc.relationHematology, Transfusion and Cell Therapy
dc.rightsAcesso Aberto
dc.subjectPh-negative myeloproliferative neoplasms
dc.subjectInflammation
dc.subjectPlasma cytokines
dc.subjectJAK2 V617F
dc.subject-
dc.titlePhiladelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation
dc.typeArtigo de Periódico


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