A cascata dos fosfoinositídeos

The phosphoinositide cascate

dc.creatorAlmeida, Mauro Vieira de
dc.creatorSilva, Adilson David da
dc.creatorSouza, Marcus Vinícius Nora de
dc.creatorBenício, Aloísio Antônio Alves
dc.date2019-02-22T12:20:38Z
dc.date2019-02-19
dc.date2019-02-22T12:20:38Z
dc.date2003-02
dc.date.accessioned2023-09-29T15:00:07Z
dc.date.available2023-09-29T15:00:07Z
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422003000100018
dc.identifierhttps://repositorio.ufjf.br/jspui/handle/ufjf/9118
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9122838
dc.descriptionInositol is a polyalcohol required for the proper formation of cell membranes. In the body, its plays an important role in the transmission of nerve impulses, its also helps in the transporting of fats within the body. In mammals, inositol exists as phosphorylated derivatives, various phosphoinositides, and in its free form. Agonist stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is the first step in the transmembrane signalling mechanism when cells respond to external stimuli. Under control of activated phospholipase C (PLC) via G-protein, two second messengers D-myo-inositol 1,4,5-triphosphate [Ins(1,4,5)P3] and diacylglycerol are released into the cell. From Ins(1,4,5)P3, enzymatic process under phosphatases or kinases control affords subsequent inositol phosphate metabolites. During the last decade the synthesis of modified inositol phosphate derivatives has been strongly investigated. This paper reviews principal aspects about synthesis and biological functions of these biomolecules.
dc.description-
dc.formatapplication/pdf
dc.languagepor
dc.publisher-
dc.publisherBrasil
dc.publisher-
dc.relationQuímica Nova
dc.rightsAcesso Aberto
dc.subjectSecond messengers
dc.subjectPhosphoinositides
dc.subjectInositol phosphate
dc.subject-
dc.titleA cascata dos fosfoinositídeos
dc.titleThe phosphoinositide cascate
dc.typeArtigo de Periódico


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