Relation between CANDIDA species isolated from vaginal mucosa and lesions caused by high-risk human papillomavirus hpv for cervical cancer

dc.creatorde Souza, Ana Clara
dc.creatorRodrigues Paula, Claudete
dc.creatorda Silva Ruiz, Luciana
dc.creatorRamos Margarido, Paulo Francisco
dc.creatorEreno Auler, Marcos
dc.creatorPaula Cristina Lorenzi, Noely
dc.creatorMoreira, Debora
dc.creatorOliveira dos Santos, Rennan Luiz
dc.creatorTacla, Maricy
dc.creatorCrosato, Edgard Michel
dc.creatorDomaneschi, Carina
dc.date2021-09-23
dc.date.accessioned2023-09-29T11:49:33Z
dc.date.available2023-09-29T11:49:33Z
dc.identifierhttps://revistas.ufg.br/iptsp/article/view/66032
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9095893
dc.descriptionThis study characterized and related yeasts of the genus Candida isolated from vaginal mucous membranes of women with lesions caused by high-risk HPV for cervical cancer. Forty-two women treated at the Lower Genital Tract Pathology Clinic of the University of São Paulo Medical School Hospital of Clinics were examined, with 30 high-grade (G1) uterine lesions with a mean age of 36.5 years ± 11. 1 and 12 with low grade (G2) uterine lesions with a mean age of 34.7 years ± 15.5. Clinical conditions and laboratory data on HPV were collected from patients’ medical records; the socio-demographic data obtained from an appropriate questionnaire. For the study of association between the variables, Odds Ratio analysis was used from the STATA 13.1 program. Patients G1 had a higher prevalence for diabetes and the results indicated 27% prevalence of Candida spp. in vaginal mucosa, in G2 this was 33% in vaginal mucosa. Among the species found in vaginal mucosa of patients, Candida albicans was the most isolated with 88%, followed by C. tropicalis (8%) and C. glabrata (4%). The strains of C. albicans isolated from mucosa presented sensitivity to all antifungal agents tested, unlike the C. tropicalis strain isolated in G2 in vaginal mucosa, which presented a resistance profile to fluconazole. Thus, monitoring and supervision through clinical and laboratory testing of HPV patients is important, reinforcing the need for care, treatment and prevention of HPV-related infections and Candida spp. KEY WORDS: vaginal mucosa; uterine cervical neoplasms; human Papillomavirus; Candida spp. Antifungal sensitivity.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversidade Federal de Goiáspt-BR
dc.relationhttps://revistas.ufg.br/iptsp/article/view/66032/37351
dc.rightsCopyright (c) 2021 Revista de Patologia Tropical / Journal of Tropical Pathologypt-BR
dc.sourceRevista de Patologia Tropical / Journal of Tropical Pathology; Vol. 50 No. 3 (2021); 212-222en-US
dc.sourceRevista de Patologia Tropical / Journal of Tropical Pathology; v. 50 n. 3 (2021); 212-222pt-BR
dc.source1980-8178
dc.source0301-0406
dc.titleRelation between CANDIDA species isolated from vaginal mucosa and lesions caused by high-risk human papillomavirus hpv for cervical canceren-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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