SEPSIS-INDUCED ACUTE KIDNEY INJURY: BIOMARKERS FOR DIAGNOSIS

dc.creatorMarcelino-Rodrigues, Vanessa
dc.creatorCaroline Silva Freitas, Ana
dc.creatorJose Figueiredo, Maria
dc.creatorReis Machado, Juliana
dc.creatorBorges de Menezes, Liliana
dc.creatorFigueiredo Soave, Danilo
dc.creatorRubia Nunes Celes, Mara
dc.date2017-09-11
dc.date.accessioned2023-09-29T11:49:20Z
dc.date.available2023-09-29T11:49:20Z
dc.identifierhttps://revistas.ufg.br/iptsp/article/view/49681
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9095810
dc.descriptionSepsis is a major global health problem leading to the increased incidence of death in intensive care units. In recent years, despite technological advances, the number of cases has grown significantly. Among the main complications presented by septic patients, acute renal dysfunction is largely responsible for the high mortality rate. Initially, the reduction of renal function is associated with focal tubular injury with preserved glomerular morphology and systemic hemodynamic alterations. During sepsis development, the progressive decreasein urinary volume and reduction of the glomerular filtration rate associated with increased serum levels of urea and creatinine are considered classic markers of severe kidney injury.Despite the valuable role of these serum markers regarding renal function, these data provide an incomplete scenario of the patient, since many renal disorders may occur in individuals with increased plasma concentrations of urea and creatinine. Taking into account the important role of systemic inflammatory processes in the development of acute kidney injury induced by sepsis, the search for new markers presenting high sensitivity and specificity capable ofdetecting early renal injury is still necessary. Thus, the present review summarizes important aspects of pathophysiology of acute kidney dysfunction induced by sepsis and presents an updated view of possible new biomarkers associated with the development of acute kidney injury. Understanding these markers allows important advances leading to new therapeutic approaches, indicating a new horizon in the diagnosis and treatment of acute kidney injury insepsis.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversidade Federal de Goiáspt-BR
dc.relationhttps://revistas.ufg.br/iptsp/article/view/49681/24414
dc.rightsCopyright (c) 2017 Revista de Patologia Tropicalpt-BR
dc.sourceRevista de Patologia Tropical / Journal of Tropical Pathology; Vol. 46 No. 3 (2017); 221-232en-US
dc.sourceRevista de Patologia Tropical / Journal of Tropical Pathology; v. 46 n. 3 (2017); 221-232pt-BR
dc.source1980-8178
dc.source0301-0406
dc.subjectSepsisen-US
dc.subjectacute kidney injuryen-US
dc.subjectdiagnostic biomarkers.en-US
dc.titleSEPSIS-INDUCED ACUTE KIDNEY INJURY: BIOMARKERS FOR DIAGNOSISen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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