Anti-M2 muscarinic receptor autoantibodies in Trypanosoma cruzi-infected pediatric patients treated with benznidazole

dc.creatorCutrullis, Romina
dc.creatorBallering, Griselda
dc.creatorAltcheh, Jaime
dc.creatorMoscatelli, Guillermo Moscatelli
dc.creatorCorral, Ricardo Corral
dc.creatorPetray, Patricia Petray
dc.creatorFreilij, Héctor
dc.date2007-10-02
dc.date.accessioned2023-09-29T11:45:58Z
dc.date.available2023-09-29T11:45:58Z
dc.identifierhttps://revistas.ufg.br/iptsp/article/view/1804
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9094619
dc.descriptionThe presence of autoantibodies with adrenergic and cholinergic activity, capable of triggeringneurotransmitter receptor-mediated effects, has been associated to pathogenesis in T. cruzi-infectedhosts. We determined the presence of anti-M2 muscarinic receptor IgG autoantibodies in 14pediatric patients with Chagas disease and 18 non-infected infants. T. cruzi-infected children showeda higher frequency and a 6.2 ± 1.8-fold increase in the level of autoantibodies to cardiac receptorswhen compared to controls. Patients were monitored since the initiation of specific treatmentwith benznidazole (Bz). Along the follow-up, we verified a significant linear decreasing trendin autoantibody reactivity. Remarkably, when treated children became seronegative for T. cruzias direct consequence of parasiticidal chemotherapy, they displayed autoantibody titers similarto those detected in healthy subjects. We conclude that, in pediatric patients, the M2 muscarinicreceptor autoantibody response is elicited early in the course of T. cruzi infection and decreases afterspecific treatment, implying that specific Bz treatment eliminates the parasite and reduces potentiallypathogenic autoimmune responses.pt-BR
dc.formatapplication/pdf
dc.languagepor
dc.publisherUniversidade Federal de Goiáspt-BR
dc.relationhttps://revistas.ufg.br/iptsp/article/view/1804/1727
dc.sourceRevista de Patologia Tropical / Journal of Tropical Pathology; Vol. 36 No. 2 (2007); 141-148en-US
dc.sourceRevista de Patologia Tropical / Journal of Tropical Pathology; v. 36 n. 2 (2007); 141-148pt-BR
dc.source1980-8178
dc.source0301-0406
dc.titleAnti-M2 muscarinic receptor autoantibodies in Trypanosoma cruzi-infected pediatric patients treated with benznidazolept-BR
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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